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Efficacy of Alendronate for Preventing Collapse of Femoral Head in Adult Patients with Nontraumatic Osteonecrosis
المؤلفون المشاركون
Hong, Yu-Cai
Luo, Ru-Bin
Lin, Tiao
Zhong, Hui-Ming
Shi, Jian-Bin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The purpose of the current review was to determine the efficacy of alendronate for preventing collapse of femoral head in adult patients with nontraumatic avascular osteonecrosis of femoral head (ANFH).
Five randomized controlled trials (RCTs) involving 305 hips were included in this review, of which 3 studies investigated alendronate versus control/placebo and the other 2 studies compared the combination of alendronate and extracorporeal shockwave therapy (ESWT) with ESWT alone.
Our results suggested that even the patients with extensive necrosis encountered much less collapse in the alendronate group than control group.
In these RCTs, their data also indicated a positive short- and middle-term efficacy of alendronate treatment in joint function improvement and hip pain diminishment.
With the presence of the outlier study, only insignificant overall efficacy of alendronate could be observed with substantial heterogeneities.
In addition, we did not find any additive benefits of alendronate in combination with ESWT for preventing collapse compared to ESWT alone.
In conclusion, there is still lack of strong evidence for supporting application of alendronate in adult patients with nontraumatic ANFH, which justified that large scale, randomized, and double-blind studies should be developed to demonstrate the confirmed efficacies, detailed indication, and optimized strategy of alendronate treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hong, Yu-Cai& Luo, Ru-Bin& Lin, Tiao& Zhong, Hui-Ming& Shi, Jian-Bin. 2014. Efficacy of Alendronate for Preventing Collapse of Femoral Head in Adult Patients with Nontraumatic Osteonecrosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016516
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hong, Yu-Cai…[et al.]. Efficacy of Alendronate for Preventing Collapse of Femoral Head in Adult Patients with Nontraumatic Osteonecrosis. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1016516
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hong, Yu-Cai& Luo, Ru-Bin& Lin, Tiao& Zhong, Hui-Ming& Shi, Jian-Bin. Efficacy of Alendronate for Preventing Collapse of Femoral Head in Adult Patients with Nontraumatic Osteonecrosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016516
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016516
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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