Intraportal Infusion of Ghrelin Could Inhibit Glucose-Stimulated GLP-1 Secretion by Enteric Neural Net in Wistar Rat

المؤلفون المشاركون

Zhang, Xiyao
Li, Wensong
Li, Ping
Chang, Manli
Huang, Xu
Li, Qiang
Cui, Can

المصدر

BioMed Research International

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-08-26

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الملخص EN

As a regulator of food intake and energy metabolism, the role of ghrelin in glucose metabolism is still not fully understood.

In this study, we determined the in vivo effect of ghrelin on incretin effect.

We demonstrated that ghrelin inhibited the glucose-stimulated release of glucagon-like peptide-1 (GLP-1) when infused into the portal vein of Wistar rat.

Hepatic vagotomy diminished the inhibitory effect of ghrelin on glucose-stimulated GLP-1 secretion.

In addition, phentolamine, a nonselective α receptor antagonist, could recover the decrease of GLP-1 release induced by ghrelin infusion.

Pralmorelin (an artificial growth hormone release peptide) infusion into the portal vein could also inhibit the glucose-stimulated release of GLP-1.

And growth hormone secretagogue receptor antagonist, [D-lys3]-GHRP-6, infusion showed comparable increases of glucose stimulated GLP-1 release compared to ghrelin infusion into the portal vein.

The data showed that intraportal infusion of ghrelin exerted an inhibitory effect on GLP-1 secretion through growth hormone secretagogue receptor 1α (GHS1α receptor), which indicated that the downregulation of ghrelin secretion after food intake was necessary for incretin effect.

Furthermore, our results suggested that the enteric neural net involved hepatic vagal nerve and sympathetic nerve mediated inhibition effect of ghrelin on incretin effect.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhang, Xiyao& Li, Wensong& Li, Ping& Chang, Manli& Huang, Xu& Li, Qiang…[et al.]. 2014. Intraportal Infusion of Ghrelin Could Inhibit Glucose-Stimulated GLP-1 Secretion by Enteric Neural Net in Wistar Rat. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1016643

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhang, Xiyao…[et al.]. Intraportal Infusion of Ghrelin Could Inhibit Glucose-Stimulated GLP-1 Secretion by Enteric Neural Net in Wistar Rat. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1016643

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhang, Xiyao& Li, Wensong& Li, Ping& Chang, Manli& Huang, Xu& Li, Qiang…[et al.]. Intraportal Infusion of Ghrelin Could Inhibit Glucose-Stimulated GLP-1 Secretion by Enteric Neural Net in Wistar Rat. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1016643

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1016643