An In Vitro Analysis of the Effects of Intravenous Lipid Emulsion on Free and Total Local Anaesthetic Concentrations in Human Blood and Plasma
المؤلفون المشاركون
Clark, Louise Ann
Beyer, Jochen
Graudins, Andis
المصدر
Critical Care Research and Practice
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Intravenous lipid emulsion (ILE) is recommended as a “rescue” treatment for local anaesthetic (LA) toxicity.
A purported mechanism of action suggests that lipophilic LAs are sequestered into an intravascular “lipid-sink,” thus reducing free drug concentration.
There is limited data available correlating the effects of ILE on LAs.
Aims.
To compare the in vitro effect of ILE on LA concentrations in human blood/plasma and to correlate this reduction to LA lipophilicity.
Method.
One of four LAs (bupivacaine-most lipophilic-4 mg/L, ropivacaine-6 mg/L, lignocaine-14 mg/L, and prilocaine-least lipophilic-7 mg/L) was spiked into plasma or whole blood.
ILE or control-buffer was added.
Plasma was centrifuged to separate ILE and total-LA concentration assayed from the lipid-free fraction.
Whole blood underwent equilibrium dialysis and free-LA concentration was measured.
Percent reduction in LA concentration from control was compared between the LAs and correlated with lipophilicity.
Results.
ILE caused a significant reduction in total and free bupivacaine concentration compared with the other LAs.
Ropivacaine had the least reduction in concentration, despite a lipophilicity similar to bupivacaine.
The reduction in LA concentration correlated to increasing lipophilicity when ropivacaine was excluded from analysis.
Conclusion.
In this first in vitro model assessing both free- and total-LA concentrations exposed to ILE in human blood/plasma, ILE effect was linearly correlated with increasing lipophilicity for all but ropivacaine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Clark, Louise Ann& Beyer, Jochen& Graudins, Andis. 2014. An In Vitro Analysis of the Effects of Intravenous Lipid Emulsion on Free and Total Local Anaesthetic Concentrations in Human Blood and Plasma. Critical Care Research and Practice،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1016691
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Beyer, Jochen…[et al.]. An In Vitro Analysis of the Effects of Intravenous Lipid Emulsion on Free and Total Local Anaesthetic Concentrations in Human Blood and Plasma. Critical Care Research and Practice No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1016691
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Clark, Louise Ann& Beyer, Jochen& Graudins, Andis. An In Vitro Analysis of the Effects of Intravenous Lipid Emulsion on Free and Total Local Anaesthetic Concentrations in Human Blood and Plasma. Critical Care Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1016691
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016691
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر