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Potential Additive Effects of Ticagrelor, Ivabradine, and Carvedilol on Sinus Node
المؤلفون المشاركون
Di Serafino, Luigi
Rotolo, Francesco Luigi
Boggi, Augusto
Colantonio, Riccardo
Serdoz, Roberto
Monti, Francesco
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-28
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
A 51-year-old male patient presented to the emergency room with an anterior ST-elevation myocardial infarction.
After a loading dose of both ticagrelor and aspirin, the patient underwent primary-PCI on the left anterior descending coronary artery with stent implantation.
After successful revascularization, medical therapy included beta-blockers, statins, and angiotensin II receptor antagonists.
Two days later, ivabradine was also administered in order to reduce heart rate at target, but the patient developed a severe symptomatic bradycardia and sinus arrest, even requiring administration of both atropine and adrenaline.
Ivabradine and ticagrelor have been then suspended and this latter changed with prasugrel.
Any other similar event was not reported during the following days.
This clinical case raised concerns about the safety of the combination of beta-blockers and ivabradine in patients treated with ticagrelor, particularly during the acute phase of an acute coronary syndrome.
These two latter drugs, in particular, might interact with the same receptor.
In fact, ivabradine directly modulates the If-channel which is also modulated by the cyclic adenosine monophosphate levels.
These latter have been shown to increase after ticagrelor assumption via inhibition of adenosine uptake by erythrocytes.
Further studies are warrant to better clarify the safety of this association.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Di Serafino, Luigi& Rotolo, Francesco Luigi& Boggi, Augusto& Colantonio, Riccardo& Serdoz, Roberto& Monti, Francesco. 2014. Potential Additive Effects of Ticagrelor, Ivabradine, and Carvedilol on Sinus Node. Case Reports in Cardiology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1016876
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Di Serafino, Luigi…[et al.]. Potential Additive Effects of Ticagrelor, Ivabradine, and Carvedilol on Sinus Node. Case Reports in Cardiology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1016876
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Di Serafino, Luigi& Rotolo, Francesco Luigi& Boggi, Augusto& Colantonio, Riccardo& Serdoz, Roberto& Monti, Francesco. Potential Additive Effects of Ticagrelor, Ivabradine, and Carvedilol on Sinus Node. Case Reports in Cardiology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1016876
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016876
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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