HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast
المؤلفون المشاركون
Kito, Katsumi
Maeda, Toshiharu
Ninomiya, Keiko
Sugita, Atsuro
Sagawa, Teiri
Matsuoka, Kinya
Kinoshita, Kousei
Hyodo, Naoki
Morita, Nagisa
Furuya, Keizo
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-18
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Apocrine carcinoma, which is strictly defined as over 90% of tumor cells showing apocrine differentiation, is a rare variant of breast cancer.
Here we report an uncommon case in which apocrine carcinomas developed concurrently in both breasts; in addition, a sarcomatoid spindle cell lesion was coincident in the right breast.
Both apocrine carcinomas were immunohistochemically negative for estrogen receptor (ER) and progesterone receptor (PgR), but diffusely positive for androgen receptor (AR), GCDFP-15, and HER2.
The presence of intraductal components in bilateral carcinomas and the absence of lymph node metastasis suggested that they were more likely to be individual primary lesions rather than metastatic disease.
The spindle cell lesion showed a relatively well-circumscribed nodule contiguous with the apocrine carcinoma.
HER2 oncoprotein overexpression was observed not only in the apocrine carcinoma, but also in the spindle cell lesion.
Since the spindle cell component was intimately admixed with apocrine carcinoma and had focal cytokeratin expression, we diagnosed it as metaplastic spindle cell carcinoma, which was originated from the apocrine carcinoma.
To our knowledge, this is the first case report of a patient with synchronous bilateral apocrine carcinomas coinciding with metaplastic carcinoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kito, Katsumi& Maeda, Toshiharu& Ninomiya, Keiko& Sugita, Atsuro& Sagawa, Teiri& Matsuoka, Kinya…[et al.]. 2014. HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast. Case Reports in Pathology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1017526
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kito, Katsumi…[et al.]. HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast. Case Reports in Pathology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1017526
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kito, Katsumi& Maeda, Toshiharu& Ninomiya, Keiko& Sugita, Atsuro& Sagawa, Teiri& Matsuoka, Kinya…[et al.]. HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast. Case Reports in Pathology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1017526
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1017526
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر