The Clinicopathologic Importance of Serum Lactic Dehydrogenase in Patients with Gastric Cancer

المؤلفون المشاركون

Zhao, Zhi
Han, Fanghai
Yang, Shibin
Hua, Lixin
Wu, Jianhai
Zhan, Wenhua

المصدر

Disease Markers

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-11-04

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأمراض

الملخص EN

To explore possible correlation between serum lactate dehydrogenase (SLDH) levels and gastric cancer.

Materials and Methods.

We retrospectively reviewed 365 patients with gastric cancer.

The correlation of SLDH levels with clinicopathologic features and survival rate was studied.

Results.

SLDH levels were closely associated with the pathological (p) T stage ( P = 0.011 ), metastasis ( P = 0.012 ), pTNM stage ( P = 0.001 ), and recurrence ( P = 0.012 ).

Moreover, we found a significant SLDH level difference among Borrmann type ( P = 0.027 ), pT stage ( P = 0.004 ), lymph node metastasis ( P = 0.027 ), metastasis ( P < 0.001 ), pTNM stage ( P = 0.006 ), and recurrence ( P = 0.002 ).

In addition, we detected a significant SLDH level difference between alive and dead subgroups ( P = 0.001 ).

In addition, both univariate analysis and multivariate analysis showed that high SLDH levels were independent prognostic factor.

For the subgroup with normal LDH (median point of 157.0 U/L), we detected that the subset with SLDH levels ≥157 U/L (158–245 U/L) showed poorer OS ( P = 0.005 ) and DFS ( P = 0.01 ) than that of ≤157 subgroup.

Conclusions.

Our results suggest that high SLDH level could be an independent poor prognostic biomarker.

Gastric cancer patients with relative high SLDH level (158–245 U/L) were prone to develop a shorter OS and DFS.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhao, Zhi& Han, Fanghai& Yang, Shibin& Hua, Lixin& Wu, Jianhai& Zhan, Wenhua. 2014. The Clinicopathologic Importance of Serum Lactic Dehydrogenase in Patients with Gastric Cancer. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1017979

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhao, Zhi…[et al.]. The Clinicopathologic Importance of Serum Lactic Dehydrogenase in Patients with Gastric Cancer. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1017979

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhao, Zhi& Han, Fanghai& Yang, Shibin& Hua, Lixin& Wu, Jianhai& Zhan, Wenhua. The Clinicopathologic Importance of Serum Lactic Dehydrogenase in Patients with Gastric Cancer. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1017979

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1017979