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High SHIP2 Expression Indicates Poor Survival in Colorectal Cancer
المؤلفون المشاركون
Yang, Ju
Fu, Maoying
Ding, Yaoguang
Weng, Yajing
Fan, Weifei
Pu, Xiaolin
Ge, Zhijun
Zhan, Feng
Ni, Huihui
Zhang, Wei
Jin, Feng
Xu, Ning
Li, Jiang
Qiu, Liang
Wang, Jun
Gu, Xuefeng
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
SH2-containing inositol 5′-phosphatase 2 (SHIP2), which generally regulates insulin signaling, cytoskeleton remodeling, and receptor endocytosis, has been suggested to play a significant role in tumor development and progression.
However, the associations between SHIP2 expression and the clinical features to evaluate its clinicopathologic significance in colorectal cancer (CRC) have not been determined yet.
In the present study, one-step quantitative real-time polymerase chain reaction (qPCR) test and immunohistochemistry (IHC) analysis with CRC tissue microarrays (TMA) were employed to evaluate the mRNA and protein expression of SHIP2 in CRC.
The results showed that SHIP2 expression in the mRNA and protein levels was significantly higher in CRC tissues than that in corresponding noncancerous tissues (both P<0.05).
The expression of SHIP2 protein in CRC was related to lymph node metastasis (P=0.036), distant metastasis (P=0.001), and overall survival (P=0.009).
Kaplan-Meier method and Cox multifactor analysis suggested that high SHIP2 protein level (P=0.040) and positive distant metastasis (P=0.048) were critically associated with the unfavorable survival of CRC patients.
The findings suggested that SHIP2 may be identified as a useful prognostic marker in CRC and targeting CRC may provide novel strategy for CRC treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Ju& Fu, Maoying& Ding, Yaoguang& Weng, Yajing& Fan, Weifei& Pu, Xiaolin…[et al.]. 2014. High SHIP2 Expression Indicates Poor Survival in Colorectal Cancer. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1017988
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Ju…[et al.]. High SHIP2 Expression Indicates Poor Survival in Colorectal Cancer. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1017988
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Ju& Fu, Maoying& Ding, Yaoguang& Weng, Yajing& Fan, Weifei& Pu, Xiaolin…[et al.]. High SHIP2 Expression Indicates Poor Survival in Colorectal Cancer. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1017988
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1017988
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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