CLCA2 as a Novel Immunohistochemical Marker for Differential Diagnosis of Squamous Cell Carcinoma from Adenocarcinoma of the Lung
المؤلفون المشاركون
Sugimura, Haruhiko
Shinmura, Kazuya
Igarashi, Hisaki
Kato, Hisami
Kawanishi, Yuichi
Inoue, Yusuke
Nakamura, Satoki
Ogawa, Hiroshi
Yamashita, Takashi
Kawase, Akikazu
Funai, Kazuhito
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-07
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Recent progress in targeted therapy for lung cancer has revealed that accurate differential diagnosis between squamous cell carcinoma (SCC) and adenocarcinoma (ADC) of the lung is essential.
To identify a novel immunohistochemical marker useful for differential diagnosis between the two subtypes of lung cancer, we first selected 24 SCC-specific genes and 6 ADC-specific genes using data (case number, 980) from the Cancer Genome Atlas (TCGA) database.
Among the genes, we chose the CLCA2 gene, which is involved in chloride conductance and whose protein expression in lung cancer is yet to be characterized, and evaluated its protein expression status in 396 cases of primary lung cancer at Hamamatsu University Hospital.
Immunohistochemical analysis revealed a significantly higher CLCA2 expression level in the SCCs than in the ADCs (P<0.0001) and also a significantly higher frequency of CLCA2 protein expression in the SCCs (104/161, 64.6%) as compared with that in the ADCs (2/235, 0.9%) (P<0.0001; sensitivity 64.6%, specificity 99.1%).
The CLCA2 protein expression status was associated with the histological tumor grade in the SCCs.
These results suggest that CLCA2 might be a novel excellent immunohistochemical marker for differentiating between primary SCC and primary ADC of the lung.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shinmura, Kazuya& Igarashi, Hisaki& Kato, Hisami& Kawanishi, Yuichi& Inoue, Yusuke& Nakamura, Satoki…[et al.]. 2014. CLCA2 as a Novel Immunohistochemical Marker for Differential Diagnosis of Squamous Cell Carcinoma from Adenocarcinoma of the Lung. Disease Markers،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1018021
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shinmura, Kazuya…[et al.]. CLCA2 as a Novel Immunohistochemical Marker for Differential Diagnosis of Squamous Cell Carcinoma from Adenocarcinoma of the Lung. Disease Markers No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1018021
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shinmura, Kazuya& Igarashi, Hisaki& Kato, Hisami& Kawanishi, Yuichi& Inoue, Yusuke& Nakamura, Satoki…[et al.]. CLCA2 as a Novel Immunohistochemical Marker for Differential Diagnosis of Squamous Cell Carcinoma from Adenocarcinoma of the Lung. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1018021
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018021
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر