Analgesia Synergism of Essential Oil from Pericarp of Zanthoxylum schinifolium and Verapamil
المؤلفون المشاركون
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
To evaluate the synergistic analgesic effect of essential oil of Zanthoxylum schinifolium Sieb.
et Zucc.
(EOZ) and verapamil (Ver).
Method.
The qualitative and quantitative composition of EOZ were determined with gas chromatography/Mass spectrometer.
The interaction between EOZ and Ver in antinociceptive activity was evaluated by using acetic acid-induced writhing, hot plate, and tail flick tests in mice and in isolated toad sciatic nerve test.
Results.
Linalool, limonene, and sabinene are the major components of EOZ.
EOZ (middle-dose: 40 mg·kg−1, high-dose: 80 mg·kg−1) and EOZ + Ver (Each dose group) have remarkable analgesic effects on pain in mice induced by acetic acid-induced writhing, hot plate, and tail flick tests.
Low-dose EOZ (20 mg·kg−1) had no analgesic action, but when it is combined with Ver it has shown significant antinociception.
Verapamil has a faint analgesic effect but was not able to inhibit action potential transmission in toad sciatic nerve.
EOZ (0.2%) and EOZ + Ver (0.2% + 0.05%) also inhibited action potential transmission in toad sciatic nerve.
Combination of EOZ with Ver had a greater analgesic effect and inhibition of nerve action potential transmission compared to its components EOZ and Ver.
Conclusion.
The combination of EOZ with Ver produces a synergistic analgesic effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Gao& Wu, Hanbin. 2014. Analgesia Synergism of Essential Oil from Pericarp of Zanthoxylum schinifolium and Verapamil. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018582
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Gao& Wu, Hanbin. Analgesia Synergism of Essential Oil from Pericarp of Zanthoxylum schinifolium and Verapamil. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1018582
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Gao& Wu, Hanbin. Analgesia Synergism of Essential Oil from Pericarp of Zanthoxylum schinifolium and Verapamil. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018582
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018582
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر