Xilei San Ameliorates Experimental Colitis in Rats by Selectively Degrading Proinflammatory Mediators and Promoting Mucosal Repair
المؤلفون المشاركون
Hao, Yongbiao
Nagase, Kazuko
Hori, Kazutoshi
Wang, Shenglan
Kogure, Yoko
Fukunaga, Ken
Kashiwamura, Shinichiro
Yamamoto, Satoshi
Nakamura, Shiro
Li, Junxiang
Miwa, Hiroto
Noguchi, Koichi
Dai, Yi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-10
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Xilei san (XLS), a herbal preparation widely used in China for erosive and ulcerative diseases, has been shown to be effective in ulcerative colitis (UC).
The present experiments were conducted to assess its efficacy and determine its mechanism of action in a rat model that resembles human UC.
The model was induced by adding 4% dextran sulfate sodium (DSS) to the rats’ drinking water for 7 days.
XLS was administered daily by retention enema from day 2 to day 7; the rats were sacrificed on day 8.
The colon tissues were obtained for further experiments.
A histological damage score and the activity of tissue myeloperoxidase were used to evaluate the severity of the colitis.
The colonic cytokine levels were detected in a suspension array, and epithelial proliferation was assessed using Ki-67 immunohistochemistry.
Intrarectal administration of XLS attenuated the DSS-induced colitis, as evidenced by a reduction in both the histological damage score and myeloperoxidase activity.
It also decreased the levels of proinflammatory cytokines, but increased the mucosal repair-related cytokines.
In addition, the epithelial Ki-67 expression was upregulated by XLS.
These results suggest that XLS attenuates DSS-induced colitis by degrading proinflammatory mediators and promoting mucosal repair.
XLS could be a potential topical treatment for human UC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hao, Yongbiao& Nagase, Kazuko& Hori, Kazutoshi& Wang, Shenglan& Kogure, Yoko& Fukunaga, Ken…[et al.]. 2014. Xilei San Ameliorates Experimental Colitis in Rats by Selectively Degrading Proinflammatory Mediators and Promoting Mucosal Repair. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018656
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hao, Yongbiao…[et al.]. Xilei San Ameliorates Experimental Colitis in Rats by Selectively Degrading Proinflammatory Mediators and Promoting Mucosal Repair. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1018656
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hao, Yongbiao& Nagase, Kazuko& Hori, Kazutoshi& Wang, Shenglan& Kogure, Yoko& Fukunaga, Ken…[et al.]. Xilei San Ameliorates Experimental Colitis in Rats by Selectively Degrading Proinflammatory Mediators and Promoting Mucosal Repair. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018656
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018656
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر