Preclinical Safety of the Root Extract of Polygala tenuifolia Willdenow in Sprague-Dawley Rats and Beagle Dogs
المؤلفون المشاركون
Shin, Ki Young
Won, Beom Young
Ha, Hyun Jee
Yun, Yeo Sang
Lee, Hyung Gun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-05
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The root of Polygala tenuifolia Willdenow has been used for the treatment of insomnia, depression, and amnesia.
However, the toxicological properties of the herb have been overlooked, because it has been used for a long time for various purposes.
In this study, we evaluated the preclinical safety of the root extract in rats and beagle dogs.
First, the acute oral toxicity was tested in both rats and dogs.
In the rats, only one female of 2 g/kg died, but no treatment-related death or clinical and gross findings were observed after the administration.
No toxicological changes or mortalities related to the test substance were also observed after the administration in the dogs.
Although vomiting, discoloration, or hemorrhage was found in some dogs, there were no serious abnormalities.
Second, the subchronic toxicity was investigated in the rats.
Two animals were found dead in the female group of 1,000 mg/kg/day, but there were no abnormal findings associated with the test substance.
There also were no adverse effects on the clinical signs, body weight, and hematological and biochemical findings.
Therefore, our results showed that the acute or subchronic toxicity of the root extract of Polygala tenuifolia might not be toxic to rats and dogs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shin, Ki Young& Won, Beom Young& Ha, Hyun Jee& Yun, Yeo Sang& Lee, Hyung Gun. 2014. Preclinical Safety of the Root Extract of Polygala tenuifolia Willdenow in Sprague-Dawley Rats and Beagle Dogs. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1018665
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shin, Ki Young…[et al.]. Preclinical Safety of the Root Extract of Polygala tenuifolia Willdenow in Sprague-Dawley Rats and Beagle Dogs. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1018665
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shin, Ki Young& Won, Beom Young& Ha, Hyun Jee& Yun, Yeo Sang& Lee, Hyung Gun. Preclinical Safety of the Root Extract of Polygala tenuifolia Willdenow in Sprague-Dawley Rats and Beagle Dogs. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1018665
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018665
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر