Antihypertensive Effect of Syzygium cumini in Spontaneously Hypertensive Rats
المؤلفون المشاركون
Ribeiro, Rachel Melo
Pinheiro Neto, Vicente Férrer
Ribeiro, Kllysmann Santos
Vieira, Denilson Amorim
Abreu, Iracelle Carvalho
Silva, Selma do Nascimento
Cartágenes, Maria do Socorro de Sousa
Freire, Sônia Maria de Farias
Borges, Antonio Carlos Romão
Borges, Marilene Oliveira da Rocha
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
This study evaluated the in vivo potential antihypertensive effect of hydroalcoholic extract of Syzygium cumini leaves (HESC) in normotensive Wistar rats and in spontaneously hypertensive rats (SHR), as well as its in vitro effect on the vascular reactivity of resistance arteries.
The hypotensive effect caused by intravenous infusion of HESC (0.01–4.0 mg/kg) in anesthetized Wistar rats was dose-dependent and was partially inhibited by pretreatment with atropine sulfate.
SHR received HESC (0.5 g/kg/day), orally, for 8 weeks and mean arterial pressure, heart rate, and vascular reactivity were evaluated.
Daily oral administration of HESC resulted in a time-dependent blood pressure reduction in SHR, with a maximum reduction of 62%.
In the endothelium-deprived superior mesenteric arteries rings the treatment with HESC reduced by 40% the maximum effect (Emax) of contraction induced by NE.
The contractile response to calcium and NE of endothelium-deprived mesenteric rings isolated from untreated SHR was reduced in a concentration-dependent manner by HESC (0.1, 0.25, and 0.5 mg/mL).
This study demonstrated that Syzygium cumini reduces the blood pressure and heart rate of SHR and that this antihypertensive effect is probably due to the inhibition of arterial tone and extracellular calcium influx.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ribeiro, Rachel Melo& Pinheiro Neto, Vicente Férrer& Ribeiro, Kllysmann Santos& Vieira, Denilson Amorim& Abreu, Iracelle Carvalho& Silva, Selma do Nascimento…[et al.]. 2014. Antihypertensive Effect of Syzygium cumini in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018730
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ribeiro, Rachel Melo…[et al.]. Antihypertensive Effect of Syzygium cumini in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1018730
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ribeiro, Rachel Melo& Pinheiro Neto, Vicente Férrer& Ribeiro, Kllysmann Santos& Vieira, Denilson Amorim& Abreu, Iracelle Carvalho& Silva, Selma do Nascimento…[et al.]. Antihypertensive Effect of Syzygium cumini in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018730
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018730
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر