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Alpha-Asarone Protects Endothelial Cells from Injury by Angiotensin II
المؤلفون المشاركون
Shi, Hai-Xia
Yang, Jiajun
Yang, Tao
Xue, Yong-Liang
Liu, Jun
Li, Ya-Juan
Zhang, Dan-Dan
Xu, Jin-Wen
Bian, Ka
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
α-Asarone is the major therapeutical constituent of Acorus tatarinowii Schott.
In this study, the potential protective effects of α-asarone against endothelial cell injury induced by angiotensin II were investigated in vitro.
The EA.hy926 cell line derived from human umbilical vein endothelial cells was pretreated with α-asarone (10, 50, 100 µmol/L) for 1 h, followed by coincubation with Ang II (0.1 µmol/L) for 24 h.
Intracellular nitric oxide (NO) and reactive oxygen species (ROS) were detected by fluorescent dyes, and phosphorylation of endothelial nitric oxide synthase (eNOS) at Ser1177 was determined by Western blotting.
α-Asarone dose-dependently mitigated the Ang II-induced intracellular NO reduction (P<0.01 versus model) and ROS production (P<0.01 versus model).
Furthermore, eNOS phosphorylation (Ser1177) by acetylcholine was significantly inhibited by Ang II, while pretreatment for 1 h with α-asarone partially prevented this effect (P<0.05 versus model).
Additionally, cell viability determined by the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay (105~114.5% versus control, P>0.05) was not affected after 24 h of incubation with α-asarone at 1–100 µmol/L.
Therefore, α-asarone protects against Ang II-mediated damage of endothelial cells and may be developed to prevent injury to cardiovascular tissues.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shi, Hai-Xia& Yang, Jiajun& Yang, Tao& Xue, Yong-Liang& Liu, Jun& Li, Ya-Juan…[et al.]. 2014. Alpha-Asarone Protects Endothelial Cells from Injury by Angiotensin II. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018874
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Hai-Xia…[et al.]. Alpha-Asarone Protects Endothelial Cells from Injury by Angiotensin II. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1018874
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shi, Hai-Xia& Yang, Jiajun& Yang, Tao& Xue, Yong-Liang& Liu, Jun& Li, Ya-Juan…[et al.]. Alpha-Asarone Protects Endothelial Cells from Injury by Angiotensin II. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018874
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018874
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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