The Correlation between Chemical Composition, as Determined by UPLC-TOF-MS, and Acute Toxicity of Veratrum nigrum L. and Radix paeoniae alba
المؤلفون المشاركون
Zhang, Xianxie
Wang, Yuguang
Liang, Qiande
Ma, Zengchun
Xiao, Chengrong
Tan, Hongling
Gao, Yue
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-12
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The eighteen incompatible medicaments is an important theory in traditional Chinese medicine.
The theory suggests that drugs in the eighteen incompatible medicaments can be toxic when used together.
Veratrum nigrum L.
and Radix paeoniae alba belong to the eighteen incompatible medicaments and have been prohibited for thousands of years.
This study offers preliminary insight into the mechanism and chemical constituents responsible for the incompatibility and toxicity of these two agents.
Specifically, we performed toxicology studies to identify and quantify the constituent substances of the two agents.
Experiments revealed that acute toxicity increases when the dose of V.
nigrum L.
is higher than, or equal to, RPA.
UPLC-TOF-MS analysis showed that, although the volumes of V.
nigrum L.
were the same, the content of some veratrum alkaloids changed significantly and had a trend toward a highly positive correlation r ≥ 0.8 with toxicity.
This suggests that the increased toxicity of the V.
nigrum L.
and RPA combination was due mainly to increased content of the special veratrum alkaloids.
The cytotoxicity of veratridine in SH-SY5Y cells was decreased with increasing paeoniflorin concentrations.
This study provides insight into the mechanism behind the incompatibility theory of TCM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Xianxie& Wang, Yuguang& Liang, Qiande& Ma, Zengchun& Xiao, Chengrong& Tan, Hongling…[et al.]. 2014. The Correlation between Chemical Composition, as Determined by UPLC-TOF-MS, and Acute Toxicity of Veratrum nigrum L. and Radix paeoniae alba. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1020379
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Xianxie…[et al.]. The Correlation between Chemical Composition, as Determined by UPLC-TOF-MS, and Acute Toxicity of Veratrum nigrum L. and Radix paeoniae alba. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1020379
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Xianxie& Wang, Yuguang& Liang, Qiande& Ma, Zengchun& Xiao, Chengrong& Tan, Hongling…[et al.]. The Correlation between Chemical Composition, as Determined by UPLC-TOF-MS, and Acute Toxicity of Veratrum nigrum L. and Radix paeoniae alba. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1020379
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1020379
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر