Potential roles of some plant parts on oxidant : antioxidant status and hyperglycemia in diabetic rat

الملخص EN

Diabetes mellitus (DM) is widely distributed all over the world including Egypt.

Hyperglycemia, oxidant/antioxidant status defect, lipid oxidation/toxicity and low- grade inflammation as major causes on diabetic complications.

Several strategies to improve these complications have been suggested.

Therefore, the present study aims to investigate the effectiveness of three most commonly plant parts powder (mulberry leaves, tomato pomace and potato peel) in modulating hyperglycemia and oxidant/antioxidant status using alloxane-induced diabetic rats.

Treatment of animals with alloxan caused a significant increased (p≤0.05) in serum glucose concentration by the ratio of 113.48% compared to normal controls.

Supplementation of the rat diets with 5% of the selected plant parts including mulberry leaves (MLP), tomato pomace powder (TPP), potato peel powder (PPP) and their mixture (Mix) leads to decrease this value by the rate of -18.25, -23.20, -20.93 and -26.80% , respectively.

The same behavior was recorded for liver tissue MDA level, the biomarkers of oxidative stress and inflammation in liver.

Also, improving in liver functions and antioxidant defense system (GSH in liver tissue, and antioxidant enzymes and vitamins in serum) in diabetic rats have been induced by different rates as the result of supplementation the diet with the studied plant parts.

All of these effects could be principally attributed to the strong antioxidant activities of these plant parts as the result of their high bioactive compounds content.

These findings provide a basis for the use of the selected plant parts powder for the prevention and early treatment of type-2 diabetes.