The Application of Three-Dimensional Collagen-Scaffolds Seeded with Myoblasts to Repair Skeletal Muscle Defects
المؤلفون المشاركون
Pan, Haiying
Holden, Kyle
Zhu, Jinhong
Ma, Jianqun
Li, Yong
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-12-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Three-dimensional (3D) engineered tissue constructs are a novel and promising approach to tissue repair and regeneration.
3D tissue constructs have the ability to restore form and function to damaged soft tissue unlike previous methods, such as plastic surgery, which are able to restore only form, leaving the function of the soft tissue often compromised.
In this study, we seeded murine myoblasts (C2C12) into a collagen composite scaffold and cultured the scaffold in a roller bottle cell culture system in order to create a 3D tissue graft in vitro.
The 3D graft created in vitro was then utilized to investigate muscle tissue repair in vivo.
The 3D muscle grafts were implanted into defect sites created in the skeletal muscles in mice.
We detected that the scaffolds degraded slowly over time, and muscle healing was improved which was shown by an increased quantity of innervated and vascularized regenerated muscle fibers.
Our results suggest that the collagen composite scaffold seeded with myoblasts can create a 3D muscle graft in vitro that can be employed for defect muscle tissue repair in vivo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Jianqun& Holden, Kyle& Zhu, Jinhong& Pan, Haiying& Li, Yong. 2011. The Application of Three-Dimensional Collagen-Scaffolds Seeded with Myoblasts to Repair Skeletal Muscle Defects. BioMed Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-1027627
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Jianqun…[et al.]. The Application of Three-Dimensional Collagen-Scaffolds Seeded with Myoblasts to Repair Skeletal Muscle Defects. BioMed Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-1027627
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Jianqun& Holden, Kyle& Zhu, Jinhong& Pan, Haiying& Li, Yong. The Application of Three-Dimensional Collagen-Scaffolds Seeded with Myoblasts to Repair Skeletal Muscle Defects. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-1027627
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1027627
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر