![](/images/graphics-bg.png)
Patients with Multiple Myeloma Develop SOX2-Specific Autoantibodies after Allogeneic Stem Cell Transplantation
المؤلفون المشاركون
Haag, Friedrich
Kobold, Sebastian
Atanackovic, Djordje
Marx, Andreas
Templin, Julia
Hildebrandt, York
Tams, Sinje
Sezer, Orhan
Reinhard, Henrike
Bokemeyer, Carsten
Bartels, Britta Marlen
Kröger, Nicolaus
Luetkens, Tim
Lajmi, Nesrine
Bartels, Katrin
Cao, Yanran
المصدر
Journal of Immunology Research
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-11-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The occurrence of SOX2-specific autoantibodies seems to be associated with an improved prognosis in patients with monoclonal gammopathy of undetermined significance (MGUS).
However, it is unclear if SOX2-specific antibodies also develop in established multiple myeloma (MM).
Screening 1094 peripheral blood (PB) sera from 196 MM patients and 100 PB sera from healthy donors, we detected SOX2-specific autoantibodies in 7.7% and 2.0% of patients and donors, respectively.
We identified SOX2211–230 as an immunodominant antibody-epitope within the full protein sequence.
SOX2 antigen was expressed in most healthy tissues and its expression did not correlate with the number of BM-resident plasma cells.
Accordingly, anti-SOX2 immunity was not related to SOX2 expression levels or tumor burden in the patients’ BM.
The only clinical factor predicting the development of anti-SOX2 immunity was application of allogeneic stem cell transplantation (alloSCT).
Anti-SOX2 antibodies occurred more frequently in patients who had received alloSCT (n=74).
Moreover, most SOX2-seropositive patients had only developed antibodies after alloSCT.
This finding indicates that alloSCT is able to break tolerance towards this commonly expressed antigen.
The questions whether SOX2-specific autoantibodies merely represent an epiphenomenon, are related to graft-versus-host effects or participate in the immune control of myeloma needs to be answered in prospective studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kobold, Sebastian& Tams, Sinje& Luetkens, Tim& Cao, Yanran& Sezer, Orhan& Bartels, Britta Marlen…[et al.]. 2011. Patients with Multiple Myeloma Develop SOX2-Specific Autoantibodies after Allogeneic Stem Cell Transplantation. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-1027699
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kobold, Sebastian…[et al.]. Patients with Multiple Myeloma Develop SOX2-Specific Autoantibodies after Allogeneic Stem Cell Transplantation. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-1027699
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kobold, Sebastian& Tams, Sinje& Luetkens, Tim& Cao, Yanran& Sezer, Orhan& Bartels, Britta Marlen…[et al.]. Patients with Multiple Myeloma Develop SOX2-Specific Autoantibodies after Allogeneic Stem Cell Transplantation. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-1027699
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1027699
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)