The Effect of Glycyrrhetinic Acid on Pharmacokinetics of Cortisone and Its Metabolite Cortisol in Rats
المؤلفون المشاركون
Li, Wan-Shu
Wang, Zhe
Wang, Shuang-Hu
Ge, Ren-Shan
Hu, Guo-Xin
Chen, Lian-Guo
Sun, Wei
Lin, Dan
Chen, Xiao-Le
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-01
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The purpose of this paper is to study pharmacokinetics of cortisone (E) and its metabolite cortisol (F) in rats after administration of glycyrrhetinic acid (GA) and cortisone.
Healthy male SD rats were randomized to be given 20 mg/kg E or E combined with 10 mg/kg GA.
Blood samples were collected at 5, 10, 20, 40, 60, 90, 120, 150, 180, and 240 min after administration.
The serum concentrations of E and F were determined by HLPC and pharmacokinetic parameters were calculated using DASver2.0 software.
The parameters of AUC(0−t), AUC(0−∞), and Cmax for E in the group of E + GA were significantly higher than those in the group of E (P<0.01); the half-time (t1/2β) was extended compared to E (P<0.05) and CL/F was dropped obviously (P<0.01).
The rise in AUC(0−t), AUC(0−∞), and Cmax for cortisol in the group of E + GA was significantly compared to the group of E (P<0.01).
CL/F was lower than E (P<0.01) and the half-time (t1/2β) was slightly extended.
In this study, we find that GA restrains the metabolism of E and F and thus increases AUC, t1/2β, and Cmax of E and F, which may be related to its inhibition effect on 11β-hydroxysteroid dehydrogenase (11β-HSD).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Dan& Sun, Wei& Wang, Zhe& Chen, Lian-Guo& Chen, Xiao-Le& Wang, Shuang-Hu…[et al.]. 2012. The Effect of Glycyrrhetinic Acid on Pharmacokinetics of Cortisone and Its Metabolite Cortisol in Rats. BioMed Research International،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1027937
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Dan…[et al.]. The Effect of Glycyrrhetinic Acid on Pharmacokinetics of Cortisone and Its Metabolite Cortisol in Rats. BioMed Research International No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-1027937
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Dan& Sun, Wei& Wang, Zhe& Chen, Lian-Guo& Chen, Xiao-Le& Wang, Shuang-Hu…[et al.]. The Effect of Glycyrrhetinic Acid on Pharmacokinetics of Cortisone and Its Metabolite Cortisol in Rats. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1027937
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1027937
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر