Evidence for Inhibitory Effects of Flupirtine, a Centrally Acting Analgesic, on Delayed Rectifier K+ Currents in Motor Neuron-Like Cells
المؤلفون المشاركون
Wu, S.-N.
Hsu, Ming-Chun
Liao, Yu-Kai
Wu, Fang-Tzu
Jong, Yuh-Jyh
Lo, Yi-Ching
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Flupirtine (Flu), a triaminopyridine derivative, is a centrally acting, non-opiate analgesic agent.
In this study, effects of Flu on K+ currents were explored in two types of motor neuron-like cells.
Cell exposure to Flu decreased the amplitude of delayed rectifier K+ current (IK(DR)) with a concomitant raise in current inactivation in NSC-34 neuronal cells.
The dissociation constant for Flu-mediated increase of IK(DR) inactivation rate was about 9.8 μM.
Neither linopirdine (10 μM), NMDA (30 μM), nor gabazine (10 μM) reversed Flu-induced changes in IK(DR) inactivation.
Addition of Flu shifted the inactivation curve of IK(DR) to a hyperpolarized potential.
Cumulative inactivation for IK(DR) was elevated in the presence of this compound.
Flu increased the amplitude of M-type K+ current (IK(M)) and produced a leftward shift in the activation curve of IK(M).
In another neuronal cells (NG108-15), Flu reduced IK(DR) amplitude and enhanced the inactivation rate of IK(DR).
The results suggest that Flu acts as an open-channel blocker of delayed-rectifier K+ channels in motor neurons.
Flu-induced block of IK(DR) is unlinked to binding to NMDA or GABA receptors and the effects of this agent on K+ channels are not limited to its action on M-type K+ channels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, S.-N.& Hsu, Ming-Chun& Liao, Yu-Kai& Wu, Fang-Tzu& Jong, Yuh-Jyh& Lo, Yi-Ching. 2012. Evidence for Inhibitory Effects of Flupirtine, a Centrally Acting Analgesic, on Delayed Rectifier K+ Currents in Motor Neuron-Like Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028011
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, S.-N.…[et al.]. Evidence for Inhibitory Effects of Flupirtine, a Centrally Acting Analgesic, on Delayed Rectifier K+ Currents in Motor Neuron-Like Cells. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028011
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, S.-N.& Hsu, Ming-Chun& Liao, Yu-Kai& Wu, Fang-Tzu& Jong, Yuh-Jyh& Lo, Yi-Ching. Evidence for Inhibitory Effects of Flupirtine, a Centrally Acting Analgesic, on Delayed Rectifier K+ Currents in Motor Neuron-Like Cells. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028011
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028011
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر