Activations of Both Extrinsic and Intrinsic Pathways in HCT 116 Human Colorectal Cancer Cells Contribute to Apoptosis through p53-Mediated ATMFas Signaling by Emilia sonchifolia Extract, a Folklore Medicinal Plant
المؤلفون المشاركون
Chung, Jing-Gung
Lan, Yu-Hsuan
Wu, Tian-Shung
Jhan, Jia-Hua
Lin, Kuei-Li
Pai, Shu-Jen
Chiu, Yu-Jen
Tsuzuki, Minoru
Yang, Jai-Sing
Chiang, Jo-Hua
Huang, Wen-Wen
Lu, Chi-Cheng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-28
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Emilia sonchifolia (L.) DC (Compositae), an herbaceous plant found in Taiwan and India, is used as folk medicine.
The clinical applications include inflammation, rheumatism, cough, cuts fever, dysentery, analgesic, and antibacteria.
The activities of Emilia sonchifolia extract (ESE) on colorectal cancer cell death have not been fully investigated.
The purpose of this study explored the induction of apoptosis and its molecular mechanisms in ESE-treated HCT 116 human colorectal cancer cells in vitro.
The methanolic ESE was characterized, and γ-humulene was formed as the major constituent (63.86%).
ESE induced cell growth inhibition in a concentration- and time-dependent response by MTT assay.
Apoptotic cells (DNA fragmentation, an apoptotic catachrestic) were found after ESE treatment by TUNEL assay and DNA gel electrophoresis.
Alternatively, ESE stimulated the activities of caspase-3, -8, and -9 and their specific caspase inhibitors protected against ESE-induced cytotoxicity.
ESE promoted the mitochondria-dependent and death-receptor-associated protein levels.
Also, ESE increased ROS production and upregulated the levels of ATM, p53, and Fas in HCT 116 cells.
Strikingly, p53 siRNA reversed ESE-reduced viability involved in p53-mediated ATM/Fas signaling in HCT 116 cells.
In summary, our result is the first report suggesting that ESE may be potentially efficacious in the treatment of colorectal cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lan, Yu-Hsuan& Chiang, Jo-Hua& Huang, Wen-Wen& Lu, Chi-Cheng& Chung, Jing-Gung& Wu, Tian-Shung…[et al.]. 2012. Activations of Both Extrinsic and Intrinsic Pathways in HCT 116 Human Colorectal Cancer Cells Contribute to Apoptosis through p53-Mediated ATMFas Signaling by Emilia sonchifolia Extract, a Folklore Medicinal Plant. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1028158
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lan, Yu-Hsuan…[et al.]. Activations of Both Extrinsic and Intrinsic Pathways in HCT 116 Human Colorectal Cancer Cells Contribute to Apoptosis through p53-Mediated ATMFas Signaling by Emilia sonchifolia Extract, a Folklore Medicinal Plant. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-1028158
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lan, Yu-Hsuan& Chiang, Jo-Hua& Huang, Wen-Wen& Lu, Chi-Cheng& Chung, Jing-Gung& Wu, Tian-Shung…[et al.]. Activations of Both Extrinsic and Intrinsic Pathways in HCT 116 Human Colorectal Cancer Cells Contribute to Apoptosis through p53-Mediated ATMFas Signaling by Emilia sonchifolia Extract, a Folklore Medicinal Plant. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1028158
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028158
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر