Mulberry Fruit Extract Protects against Memory Impairment and Hippocampal Damage in Animal Model of Vascular Dementia

المؤلفون المشاركون

Kaewkaen, Pratchaya
Wattanathorn, Jintanaporn
Muchimapura, Supaporn
Kaewrueng, Wiroje
Wongcharoenwanakit, Sathaporn
Tong-Un, Terdthai

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-08-16

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Nowadays, the preventive strategy of vascular dementia, one of the challenge problems of elderly, has received attention due to the limitation of therapeutic efficacy.

In this study, we aimed to determine the protective effect and possible mechanism of action of mulberry fruit extract on memory impairment and brain damage in animal model of vascular dementia.

Male Wistar rats, weighing 300–350 g, were orally given mulberry extract at doses of 2, 10 and 50 mg/kg at a period of 7 days before and 21 days after the occlusion of right middle cerebral artery (Rt.MCAO).

It was found that rats subjected to mulberry fruits plus Rt.MCAO showed the enhanced memory, the increased densities of neuron, cholinergic neuron, Bcl-2-immunopositive neuron together with the decreased oxidative stress in hippocampus.

Taken all data together, the cognitive enhancing effect of mulberry fruit extract observed in this study might be partly associated with the increased cholinergic function and its neuroprotective effect in turn occurs partly via the decreased oxidative stress and apoptosis.

Therefore, mulberry fruit is the potential natural cognitive enhancer and neuroprotectant.

However, further researches are essential to elucidate the possible active ingredient.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kaewkaen, Pratchaya& Tong-Un, Terdthai& Wattanathorn, Jintanaporn& Muchimapura, Supaporn& Kaewrueng, Wiroje& Wongcharoenwanakit, Sathaporn. 2012. Mulberry Fruit Extract Protects against Memory Impairment and Hippocampal Damage in Animal Model of Vascular Dementia. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028200

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kaewkaen, Pratchaya…[et al.]. Mulberry Fruit Extract Protects against Memory Impairment and Hippocampal Damage in Animal Model of Vascular Dementia. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028200

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kaewkaen, Pratchaya& Tong-Un, Terdthai& Wattanathorn, Jintanaporn& Muchimapura, Supaporn& Kaewrueng, Wiroje& Wongcharoenwanakit, Sathaporn. Mulberry Fruit Extract Protects against Memory Impairment and Hippocampal Damage in Animal Model of Vascular Dementia. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028200

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1028200