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Inhibitory Effects of Daiokanzoto (Da-Huang-Gan-Cao-Tang) on P-Glycoprotein
المؤلفون المشاركون
Ikarashi, Nobutomo
Watanabe, Yuka
Satoh, Toshiyuki
Ito, Kiyomi
Sugiyama, Kiyoshi
Ochiai, Wataru
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-27
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
We have studied the effects of various Kampo medicines on P-glycoprotein (P-gp), a drug transporter, in vitro.
The present study focused on Daiokanzoto (Da-Huang-Gan-Cao-Tang), which shows the most potent inhibitory effects on P-gp among the 50 Kampo medicines studied, and investigated the P-gp inhibitory effects of Daiokanzoto herbal ingredients (rhubarb and licorice root) and their components by an ATPase assay using human P-gp membrane.
Both rhubarb and licorice root significantly inhibited ATPase activity, and the effects of rhubarb were more potent than those of licorice root.
The content of rhubarb in Daiokanzoto is double that in licorice root, and the inhibition patterns of Daiokanzoto and rhubarb involve both competitive and noncompetitive inhibition, suggesting that the inhibitory effects of Daiokanzoto are mainly due to rhubarb.
Concerning the components of rhubarb, concentration-dependent inhibitory effects were observed for (−)-catechin gallate, (−)-epicatechin gallate, and (−)-epigallocatechin gallate.
In conclusion, rhubarb may cause changes in the drug dispositions of P-gp substrates through the inhibition of P-gp.
It appears that attention should be given to the interactions between these drugs and Kampo medicines containing rhubarb as an herbal ingredient.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Watanabe, Yuka& Ikarashi, Nobutomo& Satoh, Toshiyuki& Ito, Kiyomi& Ochiai, Wataru& Sugiyama, Kiyoshi. 2012. Inhibitory Effects of Daiokanzoto (Da-Huang-Gan-Cao-Tang) on P-Glycoprotein. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028269
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Watanabe, Yuka…[et al.]. Inhibitory Effects of Daiokanzoto (Da-Huang-Gan-Cao-Tang) on P-Glycoprotein. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028269
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Watanabe, Yuka& Ikarashi, Nobutomo& Satoh, Toshiyuki& Ito, Kiyomi& Ochiai, Wataru& Sugiyama, Kiyoshi. Inhibitory Effects of Daiokanzoto (Da-Huang-Gan-Cao-Tang) on P-Glycoprotein. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028269
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028269
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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