Gastroprotective Activity of Polygonum chinense Aqueous Leaf Extract on Ethanol-Induced Hemorrhagic Mucosal Lesions in Rats
المؤلفون المشاركون
Hajrezaei, Maryam
Hassandarvish, Pouya
Abdulla, Mahmood Ameen
Ismail, Iza Farhana
Abdul Majid, Nazia
Hazni, Hazrina
al-Bayaty, Fouad
Kadir, Farkaad A.
Awang, Khalijah
Golbabapour, Shahram
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Polygonum chinense is a Malaysian ethnic plant with various healing effects.
This study was to determine preventive effect of aqueous leaf extract of P.
chinense against ethanol-induced gastric mucosal injury in rats.
Sprague Dawley rats were divided into seven groups.
The normal and ulcer control groups were orally administered with distilled water.
The reference group was orally administered with 20 mg/kg omeprazole.
The experimental groups received the extracts 62.5, 125, 250, and 500 mg/kg, accordingly.
After sixty minutes, distilled water and absolute ethanol were given (5 mL/kg) to the normal control and the others, respectively.
In addition to histology, immunohistochemical and periodic acid schiff (PAS) stains, levels of lipid peroxidation, malondialdehyde (MDA), antioxidant enzymes, and superoxide dismutase (SOD) were measured.
The ulcer group exhibited severe mucosal damages.
The experimental groups significantly reduced gastric lesions and MDA levels and increased SOD level.
Immunohistochemistry of the experimental groups showed upregulation and downregulation of Hsp70 and Bax proteins, respectively.
PAS staining in these groups exhibited intense staining as compared to the ulcer group.
Acute toxicity study revealed the nontoxic nature of the extract.
Our data provide first evidence that P.
chinense extract could significantly prevent gastric ulcer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ismail, Iza Farhana& Golbabapour, Shahram& Hassandarvish, Pouya& Hajrezaei, Maryam& Abdul Majid, Nazia& Kadir, Farkaad A.…[et al.]. 2012. Gastroprotective Activity of Polygonum chinense Aqueous Leaf Extract on Ethanol-Induced Hemorrhagic Mucosal Lesions in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028292
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ismail, Iza Farhana…[et al.]. Gastroprotective Activity of Polygonum chinense Aqueous Leaf Extract on Ethanol-Induced Hemorrhagic Mucosal Lesions in Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028292
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ismail, Iza Farhana& Golbabapour, Shahram& Hassandarvish, Pouya& Hajrezaei, Maryam& Abdul Majid, Nazia& Kadir, Farkaad A.…[et al.]. Gastroprotective Activity of Polygonum chinense Aqueous Leaf Extract on Ethanol-Induced Hemorrhagic Mucosal Lesions in Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028292
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028292
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر