Protective Effects of the Traditional Herbal Formula Oryeongsan Water Extract on Ethanol-Induced Acute Gastric Mucosal Injury in Rats
المؤلفون المشاركون
Shin, Hyeun-Kyoo
Jeon, Woo-Young
Lim, Hye-Sun
Lee, Mi-Young
Shin, In-Shik
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
This study was performed to evaluate the protective effect and safety of Oryeongsan water extract (OSWE) on ethanol-induced acute gastric mucosal injury and an acute toxicity study in rats.
Acute gastric lesions were induced via intragastric oral administration of absolute ethanol at a dose of 5 mL/kg.
OSWE (100 and 200 mg/kg) was administered to rats 2 h prior to the oral administration of absolute ethanol.
The stomach of animal models was opened and gastric mucosal lesions were examined.
Gastric mucosal injuries were evaluated by measuring the levels of malondialdehyde (MDA), glutathione (GSH), and the activity of antioxidant enzymes.
In the acute toxicity study, no adverse effects of OSWE were observed at doses up to 2000 mg/kg/day.
Administration of OSWE reduced the damage by conditioning the gastric mucosa against ethanol-induced acute gastric injury, which included hemorrhage, hyperemia, and loss of epithelial cells.
The level of MDA was reduced in OSWE-treated groups compared with the ethanol-induced group.
Moreover, the level of GSH and the activity of antioxidant enzymes were significantly increased in the OSWE-treated groups.
Our findings suggest that OSWE has a protective effect on the gastric mucosa against ethanol-induced acute gastric injury via the upregulation of antioxidant enzymes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jeon, Woo-Young& Lee, Mi-Young& Shin, In-Shik& Lim, Hye-Sun& Shin, Hyeun-Kyoo. 2012. Protective Effects of the Traditional Herbal Formula Oryeongsan Water Extract on Ethanol-Induced Acute Gastric Mucosal Injury in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028317
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jeon, Woo-Young…[et al.]. Protective Effects of the Traditional Herbal Formula Oryeongsan Water Extract on Ethanol-Induced Acute Gastric Mucosal Injury in Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028317
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jeon, Woo-Young& Lee, Mi-Young& Shin, In-Shik& Lim, Hye-Sun& Shin, Hyeun-Kyoo. Protective Effects of the Traditional Herbal Formula Oryeongsan Water Extract on Ethanol-Induced Acute Gastric Mucosal Injury in Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028317
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028317
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر