Analgesic and Antiinflammatory Activities of the Aqueous Extract from Plectranthus amboinicus (Lour.) Spreng. Both In Vitro and In Vivo
المؤلفون المشاركون
Peng, Wen-Huang
Chiu, Yung-Jia
Huang, Tai-Hung
Lu, Tsung-Chun
Chen, Ya-Wen
Chen, Chiu-Yuan
Chiu, Chuan-Sung
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-07-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Plectranthus amboinicus (Lour.) Spreng.
is a native Labiatae plant of Taiwan.
The plants are commonly used in Chinese folk medicine for the treatment of cough, fever, sore throats, mumps, and mosquito bite.
The aim of this study was to investigate the analgesic and antiinflammatory properties of the aqueous extract from Plectranthus amboinicus (PA) in vivo and in vitro.
PA inhibited pain induced by acetic acid and formalin, and inflammation induced by carrageenan.
The anti-inflammatory effect of PA was related to modulating antioxidant enzymes' activities in the liver and decreasing the Malondialdehyde (MDA) level and the production of tumor necrosis factor alpha (TNF-α), and cyclooxygenase2 (COX-2) in edema-paw tissue in mice.
In vitro studies show that PA inhibited the proinflammatory mediators in RAW 264.7 cells stimulated with lipopolysaccharide (LPS).
PA blocked the degradation of IκB-α and nuclear translocation of NF-κB p65 subunit.
Finally, the amount of carvacrol in the aqueous extract of PA was 1.88 mg/g extract.
Our findings suggest that PA has analgesic and anti-inflammatory activities.
These effects were mediated by inhibiting the proinflammatory mediators through blocking NF-κB activation.
Meanwhile, the effects observed in this study provide evidence for folkloric uses of Plectranthus amboinicus (Lour.) Spreng.
in relieving pain and inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chiu, Yung-Jia& Huang, Tai-Hung& Chiu, Chuan-Sung& Lu, Tsung-Chun& Chen, Ya-Wen & Peng, Wen-Huang…[et al.]. 2011. Analgesic and Antiinflammatory Activities of the Aqueous Extract from Plectranthus amboinicus (Lour.) Spreng. Both In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028364
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chiu, Yung-Jia…[et al.]. Analgesic and Antiinflammatory Activities of the Aqueous Extract from Plectranthus amboinicus (Lour.) Spreng. Both In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028364
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chiu, Yung-Jia& Huang, Tai-Hung& Chiu, Chuan-Sung& Lu, Tsung-Chun& Chen, Ya-Wen & Peng, Wen-Huang…[et al.]. Analgesic and Antiinflammatory Activities of the Aqueous Extract from Plectranthus amboinicus (Lour.) Spreng. Both In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028364
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028364
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر