Differential Association of Uncoupling Protein 2 Polymorphisms with Pattern Identification among Korean Stroke Patients: A Diagnostic System in Traditional Korean Medicine
المؤلفون المشاركون
Ko, Mi Mi
Lim, Ji Hye
Lee, Hoyoung
Go, Ho Yeon
Moon, Tae-Woong
Cha, Min Ho
Lee, Myeong Soo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Uncoupling protein 2 (UCP2), a mitochondrial protein present in many organs and cell types, is known to dissipate the proton gradient formed by the electron transport chain.
Its function is correlated with predictive parameters, such as obesity, diabetes, and metabolic syndromes.
We analyzed the distribution of UCP2 polymorphisms in stroke patients diagnosed with one of the following four stroke subtypes based on the TKM standard pattern identification (PI): Qi-deficiency (QD), Dampness and Phlegm (D&P), Yin-deficiency (YD), and Fire and Heat (F&D).
We studied a total of 1,786 stroke patients (397/QD, 645/D&P, 223/YD, and 522/F&D, 586/normal).
Genotyping for the G-1957A, G-866A and A55V UCP2 polymorphisms was performed using the TaqMan.
G-866A and A55V were significantly associated with the D&P and H&F subtypes.
The frequency of subjects with the A allele of G-866A was significantly lower than the frequency of subjects with the GG type.
The A55V polymorphism was also shown similar effect with G-866A in the dominant model.
In contrast, no SNPs were shown to be associated with the QD or YD subtypes in this study.
These results showed that the G-866A and A55V UCP2 polymorphisms may be genetic factors for specific PI types among Korean stroke patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lim, Ji Hye& Ko, Mi Mi& Lee, Hoyoung& Go, Ho Yeon& Moon, Tae-Woong& Cha, Min Ho…[et al.]. 2012. Differential Association of Uncoupling Protein 2 Polymorphisms with Pattern Identification among Korean Stroke Patients: A Diagnostic System in Traditional Korean Medicine. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028384
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lim, Ji Hye…[et al.]. Differential Association of Uncoupling Protein 2 Polymorphisms with Pattern Identification among Korean Stroke Patients: A Diagnostic System in Traditional Korean Medicine. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028384
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lim, Ji Hye& Ko, Mi Mi& Lee, Hoyoung& Go, Ho Yeon& Moon, Tae-Woong& Cha, Min Ho…[et al.]. Differential Association of Uncoupling Protein 2 Polymorphisms with Pattern Identification among Korean Stroke Patients: A Diagnostic System in Traditional Korean Medicine. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028384
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028384
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر