Effect of Cymbopogon citratus and Citral on Vascular Smooth Muscle of the Isolated Thoracic Rat Aorta
المؤلفون المشاركون
Sim, Si Mui
Devi, R. Chitra
Ismail, R.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Cymbopogon citratus has been shown to have antioxidant, antimicrobial, antispasmodic and chemo-protective properties.
Citral, is the major constituent of C.
citratus.
This study investigated the effects of methanolic extracts of leaves (LE), stems (SE), and roots (RE) of C.
citratus and citral on vascular smooth muscle and explored their possible mechanisms of action.
The experiment was conducted using isolated tissue preparations, where citral, LE, SE, and RE were added separately into a tissue bath that contained aortic rings, which were pre-contracted with phenylephrine (PE).
Citral, LE, and RE exhibited a dose-dependent relaxant effect on the PE-induced contractions.
Citral appeared to partially act via NO as its vasorelaxant effect was attenuated by L-NAME.
However, the effect of LE may involve prostacyclin as indomethacin reversed the relaxant effect of LE on the PE-induced contraction.
Furthermore, citral, LE, and RE abolished the restoration of PE-induced contraction caused by the addition of increasing doses of calcium in both endothelium intact and denuded rings.
These findings suggest that the relaxation effect of citral, LE, and RE is endothelium-independent and may be mainly by affecting the intracellular concentration of calcium.
Citral may partially act through the NO pathway while a vasodilator prostaglandin may mediate the effect of LE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Devi, R. Chitra& Sim, Si Mui& Ismail, R.. 2012. Effect of Cymbopogon citratus and Citral on Vascular Smooth Muscle of the Isolated Thoracic Rat Aorta. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028387
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Devi, R. Chitra…[et al.]. Effect of Cymbopogon citratus and Citral on Vascular Smooth Muscle of the Isolated Thoracic Rat Aorta. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028387
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Devi, R. Chitra& Sim, Si Mui& Ismail, R.. Effect of Cymbopogon citratus and Citral on Vascular Smooth Muscle of the Isolated Thoracic Rat Aorta. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028387
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028387
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر