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Antioxidant Activity and Hepatoprotective Potential of Polyalthia longifolia and Cassia spectabilis Leaves against Paracetamol-Induced Liver Injury
المؤلفون المشاركون
Chen, Yeng
Jothy, Subramanion L.
Aziz, Azlan
Sasidharan, Sreenivasan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
In the present study, in vitro antioxidant, free radical scavenging capacity, and hepatoprotective activity of methanol extracts from Polyalthia longifolia and Cassia spectabilis were evaluated using established in vitro models such as ferric-reducing antioxidant power (FRAP), 2,2-diphenyl-1-picryl-hydrazyl (DPPH•), hydroxyl radical (OH•), nitric oxide radical (NO•) scavenging, metal chelating, and antilipidperoxidation activities.
Interestingly, all the extracts showed considerable in vitro antioxidant and free radical scavenging activities in a dose-dependent manner when compared to the standard antioxidant which verified the presence of strong antioxidant compound in leaf extracts tested.
Phenolic and flavonoid content of these extracts is significantly correlated with antioxidant capacity.
Since P.
longifolia extract was exhibited better in vitro antioxidant activities, it was subjected for in vivo hepatoprotective activity in paracetamol-intoxicated mice.
Therapy of P.
longifolia showed the liver protective effect on biochemical and histopathological alterations.
Moreover, histological studies also supported the biochemical finding, that is, the maximum improvement in the histoarchitecture of the liver.
Results revealed that P.
longifolia leaf extract could protect the liver against paracetamol-induced oxidative damage by possibly increasing the antioxidant protection mechanism in mice.
Our findings indicated that P.
longifolia and C.
spectabilis have potential as good sources of natural antioxidant/antiaging compounds.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jothy, Subramanion L.& Aziz, Azlan& Chen, Yeng& Sasidharan, Sreenivasan. 2012. Antioxidant Activity and Hepatoprotective Potential of Polyalthia longifolia and Cassia spectabilis Leaves against Paracetamol-Induced Liver Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028395
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jothy, Subramanion L.…[et al.]. Antioxidant Activity and Hepatoprotective Potential of Polyalthia longifolia and Cassia spectabilis Leaves against Paracetamol-Induced Liver Injury. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028395
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jothy, Subramanion L.& Aziz, Azlan& Chen, Yeng& Sasidharan, Sreenivasan. Antioxidant Activity and Hepatoprotective Potential of Polyalthia longifolia and Cassia spectabilis Leaves against Paracetamol-Induced Liver Injury. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028395
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028395
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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