Antioxidant and Protective Effects of Bupleurum falcatum on the l-Thyroxine-Induced Hyperthyroidism in Rats
المؤلفون المشاركون
Kim, Seong-Mo
Chung, In-Kwon
Cheon, Woo-Hyun
Ku, Sae-Kwang
Kim, Sang Chan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-07
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Bupleuri Radix (BR), the dried roots of Bupleurum falcatum L., has been used in folk medicine as an antiinflammatory and antioxidative agent.
The aqueous extract of BR was evaluated for its possible ameliorative effect in the regulation of hyperthyroidism in l-thyroxine- (LT4-) induced rat model.
After oral administration of 300, 150, and 75 mg/kg of BR extracts, once a day for 15 days from 12th LT4 treatments, changes on the body, thyroid gland, liver, and epididymal fat pad weights, serum triiodothyronine, thyroxine, thyroid-stimulating hormone, asparte aminotransferase and alanine aminotransferase concentrations, hepatic lipid peroxidation, glutathione contents, superoxide dismutase, and catalase activities were investigated with thyroid gland, liver, and epididymal fat histopathological changes.
The effects of BR extracts were compared with that of propylthiouracil, a standard antithyroid drug 10 mg/kg (intraperitoneally).
In this experiment, BR extracts dose dependently reversed LT4-induced hyperthyroidisms, and these effects indicating their potential in the regulation of hyperthyroidism.
Further, the BR extract normalized LT4-induced liver oxidative stresses, and also reduced liver and epididymal fat pad changes.
BR extracts 150 mg/kg showed comparable effects on the LT4-induced rat hyperthyroidism as compared with PTU 10 mg/kg.
These effects of BR may help the improvement of hyperthyroidisms and accompanied various organ damages.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Seong-Mo& Kim, Sang Chan& Chung, In-Kwon& Cheon, Woo-Hyun& Ku, Sae-Kwang. 2012. Antioxidant and Protective Effects of Bupleurum falcatum on the l-Thyroxine-Induced Hyperthyroidism in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028402
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Seong-Mo…[et al.]. Antioxidant and Protective Effects of Bupleurum falcatum on the l-Thyroxine-Induced Hyperthyroidism in Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1028402
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Seong-Mo& Kim, Sang Chan& Chung, In-Kwon& Cheon, Woo-Hyun& Ku, Sae-Kwang. Antioxidant and Protective Effects of Bupleurum falcatum on the l-Thyroxine-Induced Hyperthyroidism in Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028402
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028402
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر