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Polygonum cuspidatum Extract Induces Anoikis in Hepatocarcinoma Cells Associated with Generation of Reactive Oxygen Species and Downregulation of Focal Adhesion Kinase
المؤلفون المشاركون
Hu, Bing
An, Hong-Mei
Shen, Ke-Ping
Deng, Shan
Song, Hai-Yan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Anoikis has been recognized as a potential target for anticancer therapy.
Polygonum cuspidatum (Huzhang) is a frequently used Chinese herb in hepatocarcinoma.
In present study, we evaluated the effects of Polygonum cuspidatum extract (PCE) in hepatocarcinoma cells in suspension.
The results showed that PCE inhibited the proliferation of hepatocarcinoma cells in suspension in a dose- and time-dependent manner.
PCE also inhibited anchorage-independent growth of hepatocarcinoma cells in soft agar.
PCE induced anoikis in human hepatocarcinoma Bel-7402 cells accompanied by caspase-3 and caspase-9 activation and poly(ADP-ribose) polymerase cleavage, which was completely abrogated by a pan caspase inhibitor, Z-VAD-FMK.
In addition, PCE treatment induced intracellular reactive oxygen species (ROS) production in Bel-7402 cells.
NAC, an ROS scavenger, partially attenuated PCE-induced anoikis and activation of caspase-3 and caspase-9.
Furthermore, PCE inhibited expression of focal adhesion kinase (FAK) in Bel-7402 cells.
Overexpression of FAK partially abrogated PCE-induced anoikis.
These data suggest that PCE may inhibit suspension growth and induce caspase-mediated anoikis in hepatocarcinoma cells and may relate to ROS generation and FAK downregulation.
The present study provides new insight into the application of Chinese herb for hepatocarcinoma treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Bing& An, Hong-Mei& Shen, Ke-Ping& Song, Hai-Yan& Deng, Shan. 2012. Polygonum cuspidatum Extract Induces Anoikis in Hepatocarcinoma Cells Associated with Generation of Reactive Oxygen Species and Downregulation of Focal Adhesion Kinase. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028423
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Bing…[et al.]. Polygonum cuspidatum Extract Induces Anoikis in Hepatocarcinoma Cells Associated with Generation of Reactive Oxygen Species and Downregulation of Focal Adhesion Kinase. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028423
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Bing& An, Hong-Mei& Shen, Ke-Ping& Song, Hai-Yan& Deng, Shan. Polygonum cuspidatum Extract Induces Anoikis in Hepatocarcinoma Cells Associated with Generation of Reactive Oxygen Species and Downregulation of Focal Adhesion Kinase. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028423
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028423
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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