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Brachystemma calycinum D. Don Effectively Reduces the Locomotor Disability in Dogs with Naturally Occurring Osteoarthritis: A Randomized Placebo-Controlled Trial
المؤلفون المشاركون
Martel-Pelletier, Johanne
Pelletier, Jean-Pierre
Moreau, Maxim
Lussier, Bertrand
Bédard, Christian
Gauvin, Dominique
Troncy, Eric
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
The aim of this randomized placebo-controlled trial was to evaluate the beneficial effect of a whole plant extract of Brachystemma calycinum D.
Don (BCD) in naturally occurring osteoarthritis (OA) in dogs.
Methods.
Dogs had stifle/hip OA and poor limb loading based on the peak of the vertically oriented ground reaction force (PVF) measured using a force platform.
At baseline, PVF and case-specific outcome measure of disability (CSOM) were recorded.
Dogs (16 per group) were then assigned to receive BCD (200 mg/kg/day) or a placebo.
The PVF was measured at week (W) 3 and W6.
Locomotor activity was recorded throughout the study duration using collar-mounted accelerometer, and CSOM was assessed biweekly by the owner.
Results.
BCD-treated dogs had higher PVF at W3 and W6 when compared to Baseline (P<0.001) and at W6 when compared to placebo-treated dogs (P=0.040).
Higher daily duration (P=0.024) and intensity (P=0.012) of locomotor activity were observed in BCD-treated dogs compared to baseline.
No significant change was observed in either group for CSOM.
Conclusions.
Treatment with BCD improved the limb impairment and enhanced the locomotor activity in dogs afflicted by naturally-occurring OA.
Those preclinical findings provide interesting and new information about the potential of BCD as an OA therapeutic.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moreau, Maxim& Lussier, Bertrand& Pelletier, Jean-Pierre& Martel-Pelletier, Johanne& Bédard, Christian& Gauvin, Dominique…[et al.]. 2012. Brachystemma calycinum D. Don Effectively Reduces the Locomotor Disability in Dogs with Naturally Occurring Osteoarthritis: A Randomized Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028450
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moreau, Maxim…[et al.]. Brachystemma calycinum D. Don Effectively Reduces the Locomotor Disability in Dogs with Naturally Occurring Osteoarthritis: A Randomized Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028450
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moreau, Maxim& Lussier, Bertrand& Pelletier, Jean-Pierre& Martel-Pelletier, Johanne& Bédard, Christian& Gauvin, Dominique…[et al.]. Brachystemma calycinum D. Don Effectively Reduces the Locomotor Disability in Dogs with Naturally Occurring Osteoarthritis: A Randomized Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028450
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028450
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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