A Pilot Study for the Neuroprotective Effect of Gongjin-dan on Transient Middle Cerebral Artery Occlusion-Induced Ischemic Rat Brain
المؤلفون المشاركون
Jang, Dong-Kyu
Maeng, Lee-So
Jung, Yu Jin
Park, Moon-Seo
Lee, Jisoo
Jang, Kyung-Sool
Im, Ruth
Park, Soon A.
Kang, Eun-Sun
Kim, Min-Wook
Park, Sang In
Sunwoo, Yun-Young
Han, Young-Min
Chung, Yong-An
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
In this study, we investigated whether gongjin-dan improves functional recovery and has neuroprotective effects on reducing the infarct volume after transient middle cerebral artery occlusion (MCAo).
Infarct volume was measured using TTC staining and glucose utilization by F-18 FDG PET.
Functional improvement was evaluated with the Rota-rod, treadmill, Garcia score test, and adhesive removal test.
At 14 days after MCAo, neuronal cell survival, astrocytes expansion, and apoptosis were assessed by immunohistofluorescence staining in the peri-infarct region.
Also, the expression of neurotrophic factors and inflammatory cytokines such as VEGF, BDNF, Cox-2, TNF-α, IL-1β, and IL-1α was measured in ischemic hemisphere regions.
The gongjin-dan-treated group showed both reduced infarct volume and increased glucose utilization.
Behavior tests demonstrated a significant improvement compared to the control.
Also in the gongjin-dan treated group, NeuN-positive cells were increased and number of astrocytes, microglia, and apoptotic cells was significantly decreased compared with the control group in the ischemic peri-infarct area.
Furthermore, the expression of VEGF and BDNF was increased and level of Cox-2, TNF-α, IL-1β, and IL-1α was decreased.
These results suggest that gongjin-dan may improve functional outcome through the rapid restoration of metabolism and can be considered as a potential neuroprotective agent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sunwoo, Yun-Young& Park, Sang In& Chung, Yong-An& Lee, Jisoo& Park, Moon-Seo& Jang, Kyung-Sool…[et al.]. 2012. A Pilot Study for the Neuroprotective Effect of Gongjin-dan on Transient Middle Cerebral Artery Occlusion-Induced Ischemic Rat Brain. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028467
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sunwoo, Yun-Young…[et al.]. A Pilot Study for the Neuroprotective Effect of Gongjin-dan on Transient Middle Cerebral Artery Occlusion-Induced Ischemic Rat Brain. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028467
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sunwoo, Yun-Young& Park, Sang In& Chung, Yong-An& Lee, Jisoo& Park, Moon-Seo& Jang, Kyung-Sool…[et al.]. A Pilot Study for the Neuroprotective Effect of Gongjin-dan on Transient Middle Cerebral Artery Occlusion-Induced Ischemic Rat Brain. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028467
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028467
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر