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Fractionation of an Extract of Pluchea odorata Separates a Property Indicative for the Induction of Cell Plasticity from One That Inhibits a Neoplastic Phenotype
المؤلفون المشاركون
Seelinger, Mareike
Popescu, Ruxandra
Seephonkai, Prapairat
Singhuber, Judith
Giessrigl, Benedikt
Unger, Christine
Bauer, Sabine
Wagner, Karl-Heinz
Fritzer-Szekeres, Monika
Szekeres, Thomas
Diaz, Rene
Tut, Foster M.
Frisch, Richard
Feistel, Björn
Krupitza, Georg
Kopp, B.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-13
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Introduction.
Several studies demonstrated that anti-inflammatory remedies exhibit excellent anti-neoplastic properties.
An extract of Pluchea odorata (Asteraceae), which is used for wound healing and against inflammatory conditions, was fractionated and properties correlating to anti-neoplastic and wound healing effects were separated.
Methods.
Up to six fractionation steps using silica gel, Sephadex columns, and distinct solvent systems were used, and eluted fractions were analysed by thin layer chromatography, apoptosis, and proliferation assays.
The expression of oncogenes and proteins regulating cell migration was investigated by immunoblotting after treating HL60 cells with the most active fractions.
Results.
Sequential fractionations enriched anti-neoplastic activities which suppressed oncogene expression of JunB, c-Jun, c-Myc, and Stat3.
Furthermore, a fraction (F4.6.3) inducing or keeping up expression of the mobility markers MYPT, ROCK1, and paxillin could be separated from another fraction (F4.3.7), which inhibited these markers.
Conclusions.
Wound healing builds up scar or specific tissue, and hence, compounds enhancing cell migration support this process.
In contrast, successful anti-neoplastic therapy combats tumour progression, and thus, suppression of cell migration is mandatory.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Seelinger, Mareike& Popescu, Ruxandra& Seephonkai, Prapairat& Singhuber, Judith& Giessrigl, Benedikt& Unger, Christine…[et al.]. 2012. Fractionation of an Extract of Pluchea odorata Separates a Property Indicative for the Induction of Cell Plasticity from One That Inhibits a Neoplastic Phenotype. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028486
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Seelinger, Mareike…[et al.]. Fractionation of an Extract of Pluchea odorata Separates a Property Indicative for the Induction of Cell Plasticity from One That Inhibits a Neoplastic Phenotype. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028486
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Seelinger, Mareike& Popescu, Ruxandra& Seephonkai, Prapairat& Singhuber, Judith& Giessrigl, Benedikt& Unger, Christine…[et al.]. Fractionation of an Extract of Pluchea odorata Separates a Property Indicative for the Induction of Cell Plasticity from One That Inhibits a Neoplastic Phenotype. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028486
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028486
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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