![](/images/graphics-bg.png)
Portulaca oleracea Ameliorates Diabetic Vascular Inflammation and Endothelial Dysfunction in dbdb Mice
المؤلفون المشاركون
Kang, Dae Gill
Lee, Yun Jung
Lee, An Sook
Kim, Jin Sook
Lee, So Min
Yoon, Jung Joo
Lee, Ho Sub
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Type 2 diabetes is associated with significantly accelerated rates of micro- and macrovascular complications such as diabetic vascular inflammation and endothelial dysfunction.
In the present study, we investigated the protective effect of the aqueous extract of Portulaca oleracea L.
(AP), an edible plant used as a folk medicine, on diabetic vascular complications.
The db/db mice were treated with AP (300 mg/kg/day, p.o.) for 10 weeks, and AP treatment markedly lowered blood glucose, plasma triglyceride, plasma level of LDL-cholesterol, and systolic blood pressure in diabetic db/db mice.
Furthermore, AP significantly increased plasma level of HDL-cholesterol and insulin level.
The impairment of ACh- and SNP-induced vascular relaxation of aortic rings were ameliorated by AP treatment in diabetic db/db mice.
This study also showed that overexpression of VCAM-1, ICAM-1, E-selectin, MMP-2, and ET-1 were observed in aortic tissues of untreated db/db mice, which were significantly suppressed by treatment with AP.
We also found that the insulin immunoreactivity of the pancreatic islets remarkably increased in AP treated db/db mice compared with untreated db/db mice.
Taken together, AP suppresses hyperglycemia and diabetic vascular inflammation, and prevents the development of diabetic endothelial dysfunction for the development of diabetes and its vascular complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, An Sook& Lee, Yun Jung& Lee, So Min& Yoon, Jung Joo& Kim, Jin Sook& Kang, Dae Gill…[et al.]. 2012. Portulaca oleracea Ameliorates Diabetic Vascular Inflammation and Endothelial Dysfunction in dbdb Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028518
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, An Sook…[et al.]. Portulaca oleracea Ameliorates Diabetic Vascular Inflammation and Endothelial Dysfunction in dbdb Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028518
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, An Sook& Lee, Yun Jung& Lee, So Min& Yoon, Jung Joo& Kim, Jin Sook& Kang, Dae Gill…[et al.]. Portulaca oleracea Ameliorates Diabetic Vascular Inflammation and Endothelial Dysfunction in dbdb Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028518
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028518
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)