Pharmacokinetics of Ganoderic Acids A and F after Oral Administration of Ling Zhi Preparation in Healthy Male Volunteers
المؤلفون المشاركون
Sangdee, Chaichan
Chiranthanut, Natthakarn
Sadja, Sasinun
Ampasavate, Chadarat
Rojanasthien, Noppamas
Teekachunhatean, Supanimit
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The objectives of this paper were to evaluate the pharmacokinetics of ganoderic acids A and F after a single oral dose of the water extract of MG2-strain Ling Zhi (MG2FB-WE) and to assess the influence of food on the pharmacokinetics in 12 healthy male volunteers.
This study was a single-dose, open-label, randomized, two-phase crossover study with at least 2 wk washout period.
Each subject was randomly assigned to receive a single oral dose of 3,000 mg of MG2FB-WE in granular formulation dissolved in 200 mL of warm water, either under a fasting condition, or immediately after a standard breakfast (fed condition).
Blood samples were collected immediately before and at specific time points until 8 h after MG2FB-WE administration.
Plasma ganoderic acids A and F concentrations were determined by using liquid chromatography-mass spectrometry (LC-MS) technique.
In conclusion, the pharmacokinetic profile of both ganoderic acids under a fasting condition was characterized by rapid absorption from the gastrointestinal tract (Tmax at approximately 30 min) and a short elimination half-life (<40 min).
Food significantly decreased Cmax and delayed Tmax, but did not affect the extent of ganoderic acid A absorption.
However, concomitant food intake markedly impeded both rate and extent of ganoderic acid F absorption.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Teekachunhatean, Supanimit& Sadja, Sasinun& Ampasavate, Chadarat& Chiranthanut, Natthakarn& Rojanasthien, Noppamas& Sangdee, Chaichan. 2012. Pharmacokinetics of Ganoderic Acids A and F after Oral Administration of Ling Zhi Preparation in Healthy Male Volunteers. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028530
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Teekachunhatean, Supanimit…[et al.]. Pharmacokinetics of Ganoderic Acids A and F after Oral Administration of Ling Zhi Preparation in Healthy Male Volunteers. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028530
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Teekachunhatean, Supanimit& Sadja, Sasinun& Ampasavate, Chadarat& Chiranthanut, Natthakarn& Rojanasthien, Noppamas& Sangdee, Chaichan. Pharmacokinetics of Ganoderic Acids A and F after Oral Administration of Ling Zhi Preparation in Healthy Male Volunteers. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028530
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028530
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر