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Salvianolic Acid B Reducing Portal Hypertension Depends on Macrophages in Isolated Portal Perfused Rat Livers with Chronic Hepatitis
المؤلفون المشاركون
Jia, Hongmei
Cai, Dayong
Zou, Zhongmei
Zhao, Xin
Yang, Shijun
Zu, Chengzhe
Liu, Yuetao
Deng, Bo
Xu, Xueyan
Zhang, Tao
Zhou, Hang
Yin, He
Li, Ting
Song, Yijun
Wang, Yueqi
Li, PengTao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
This study is aimed to investigate the effects of Sal B on portal hypertension (PH).
PH with chronic hepatitis was induced by carbon tetrachloride (CCl4) in rats.
The model was confirmed with elevated portal pressures and increased serum CD163 levels.
The inducible nitric oxide synthase (iNOS) or heme oxygenase-1 (HO-1) in portal triads was assessed.
The isolated portal perfused rat liver (IPPRL) was performed at d0, d28, d56, and d84 in the progression of chronic hepatitis.
After constricting with phenylephrine, the portal veins were relaxed with Sal B.
The EC50 of Sal B for relaxing portal veins was −2.04×10−9, 7.28×10−11, 1.52×10−11, and 8.44×10−11 mol/L at d0, d28, d56, and d84, respectively.
More macrophages infiltrated in portal triads and expressed more iNOS or HO-1 as PH advanced.
The areas under the curve (AUCs) of Sal B for reducing PH were positively correlated with the levels of iNOS or HO-1 in portal triads, and so did with serum CD163 levels.
Sal B reduces PH in IPPRL with chronic hepatitis, via promoting portal relaxation due to macrophage-originated NO or CO in portal triads, partly at least.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Xin& Jia, Hongmei& Yang, Shijun& Liu, Yuetao& Deng, Bo& Xu, Xueyan…[et al.]. 2012. Salvianolic Acid B Reducing Portal Hypertension Depends on Macrophages in Isolated Portal Perfused Rat Livers with Chronic Hepatitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028536
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Xin…[et al.]. Salvianolic Acid B Reducing Portal Hypertension Depends on Macrophages in Isolated Portal Perfused Rat Livers with Chronic Hepatitis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028536
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Xin& Jia, Hongmei& Yang, Shijun& Liu, Yuetao& Deng, Bo& Xu, Xueyan…[et al.]. Salvianolic Acid B Reducing Portal Hypertension Depends on Macrophages in Isolated Portal Perfused Rat Livers with Chronic Hepatitis. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028536
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028536
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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