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Cognitive-Enhancing Effect of Quercetin in a Rat Model of Parkinson's Disease Induced by 6-Hydroxydopamine
المؤلفون المشاركون
Wattanathorn, Jintanaporn
Sriraksa, Napatr
Muchimapura, Supaporn
Tiamkao, Somsak
Brown, Kamoltip
Chaisiwamongkol, Kowit
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-07-17
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Oxidative stress has been reported to induce cognitive impairment in Parkinson's disease.
This paper aimed to determine the effect of quercetin, a substance possessing antioxidant activity, on the cognitive function in a rat model of Parkinson's disease.
Male Wistar rats, weighing 200–250 g, were orally given quercetin at doses of 100, 200, 300 mg/kg BW once daily for a period of 14 days before and 14 days after the unilateral lesion of right substantia nigra induced by 6-hydroxydopamine (6-OHDA).
Their spatial memory was assessed at 7 and 14 days of treatment and neuron density was determined, malondialdehyde (MDA) level, the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were evaluated at the end of the experiment.
In addition, the activity of acetylcholinesterase (AChE) was also measured.
It was found that all doses of quercetin enhanced spatial memory.
Therefore, it is suggested that the cognitive-enhancing effect of quercetin occurs partly because of decreased oxidative damage resulting in increased neuron density.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sriraksa, Napatr& Wattanathorn, Jintanaporn& Muchimapura, Supaporn& Tiamkao, Somsak& Brown, Kamoltip& Chaisiwamongkol, Kowit. 2011. Cognitive-Enhancing Effect of Quercetin in a Rat Model of Parkinson's Disease Induced by 6-Hydroxydopamine. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028565
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sriraksa, Napatr…[et al.]. Cognitive-Enhancing Effect of Quercetin in a Rat Model of Parkinson's Disease Induced by 6-Hydroxydopamine. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028565
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sriraksa, Napatr& Wattanathorn, Jintanaporn& Muchimapura, Supaporn& Tiamkao, Somsak& Brown, Kamoltip& Chaisiwamongkol, Kowit. Cognitive-Enhancing Effect of Quercetin in a Rat Model of Parkinson's Disease Induced by 6-Hydroxydopamine. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028565
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028565
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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