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Alleviation of Morphine Withdrawal Signs but Not Tolerance by theEssential Oil of Kelussia odoratissima Mozaff.
المؤلفون المشاركون
Sajjadi, Seyed Ebrahim
Izadi, Azadeh
Rabbani, Mohammed
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-04
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The aim of the present study was to assess the effects of chronic and acute treatment of the essential oil (EO) of Kelussia odoratissima Mozaff.
on the development of morphine tolerance and dependence in mice.
Mice were rendered tolerant to and dependent on morphine by subcutaneous injection of morphine over a period of 5 days.
Tolerance was assessed using the tail-pinch test and withdrawal signs of morphine were precipitated by injecting naloxone 2 h after the final morphine injection.
Repeated injection of the EO of K.
odoratissima (5 and 10 mg/kg) for 4 days significantly suppressed morphine-withdrawal jumps, a sign of the development of dependence to opiate as assessed by naloxone precipitation withdrawal on day 5 of testing.
A single injection (25, 50, 100 mg/kg) of the EO on day 5, 1 h prior to morphine failed to produce any significant change in morphine withdrawal signs.
Neither the acute nor the chronic administration of EO of the K.
odoratissima did significantly influence the development of tolerance to the analgesic effect of morphine.
Alleviation in morphine signs of withdrawal after chronic injection with K.
odoratissima is indicative of reversal of neuronal adaptation that takes place during morphine presence in the brain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rabbani, Mohammed& Sajjadi, Seyed Ebrahim& Izadi, Azadeh. 2012. Alleviation of Morphine Withdrawal Signs but Not Tolerance by theEssential Oil of Kelussia odoratissima Mozaff.. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028582
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rabbani, Mohammed…[et al.]. Alleviation of Morphine Withdrawal Signs but Not Tolerance by theEssential Oil of Kelussia odoratissima Mozaff.. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028582
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rabbani, Mohammed& Sajjadi, Seyed Ebrahim& Izadi, Azadeh. Alleviation of Morphine Withdrawal Signs but Not Tolerance by theEssential Oil of Kelussia odoratissima Mozaff.. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028582
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028582
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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