Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus), Prevents Platelet Activation in Human Platelets
المؤلفون المشاركون
Lu, Wan-Jung
Chou, Hsiu-Chu
Lee, Ye-Ming
Hsieh, Kuo-Hsien
Lin, Kuan-Hung
Chou, Duen-Suey
Sheu, Joen-Rong
Lien, Li-Ming
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Xanthohumol is the principal prenylated flavonoid in the hop plant (Humulus lupulus L.).
Xanthohumol was found to be a very potent cancer chemopreventive agent through regulation of diverse mechanisms.
However, no data are available concerning the effects of xanthohumol on platelet activation.
The aim of this paper was to examine the antiplatelet effect of xanthohumol in washed human platelets.
In the present paper, xanthohumol exhibited more-potent activity in inhibiting platelet aggregation stimulated by collagen.
Xanthohumol inhibited platelet activation accompanied by relative [Ca2+]i mobilization, thromboxane A2 formation, hydroxyl radical (OH●) formation, and phospholipase C (PLC)γ2, protein kinase C (PKC), mitogen-activated protein kinase (MAPK), and Akt phosphorylation.
Neither SQ22536, an inhibitor of adenylate cyclase, nor ODQ, an inhibitor of guanylate cyclase, reversed the xanthohumol-mediated inhibitory effect on platelet aggregation.
Furthermore, xanthohumol did not significantly increase nitrate formation in platelets.
This study demonstrates for the first time that xanthohumol possesses potent antiplatelet activity which may initially inhibit the PI3-kinase/Akt, p38 MAPK, and PLCγ2-PKC cascades, followed by inhibition of the thromboxane A2 formation, thereby leading to inhibition of [Ca2+]i and finally inhibition of platelet aggregation.
Therefore, this novel role of xanthohumol may represent a high therapeutic potential for treatment or prevention of cardiovascular diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Ye-Ming& Hsieh, Kuo-Hsien& Lu, Wan-Jung& Chou, Hsiu-Chu& Chou, Duen-Suey& Lien, Li-Ming…[et al.]. 2012. Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus), Prevents Platelet Activation in Human Platelets. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028584
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Ye-Ming…[et al.]. Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus), Prevents Platelet Activation in Human Platelets. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028584
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Ye-Ming& Hsieh, Kuo-Hsien& Lu, Wan-Jung& Chou, Hsiu-Chu& Chou, Duen-Suey& Lien, Li-Ming…[et al.]. Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus), Prevents Platelet Activation in Human Platelets. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028584
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028584
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر