The Effects of Jiang-Zhi-Ning and Its Main Components on Cholesterol Metabolism
المؤلفون المشاركون
Chen, Jianxin
Zhao, Huihui
Wang, Wei
Luo, Liangtao
Ma, Xueling
Han, Xiao
Wang, Luya
Han, Jing
Liu, Bing
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
To examine how Jiang-Zhi-Ning (JZN) regulates cholesterol metabolism and compare the role of its four main components.
We established a beagle model of hyperlipidemia, fed with JZN extract and collected JZN-containing serum 0, 1, 2, 4, and 6 h later.
Human liver cells Bel-7402 were stimulated with 10% JZN-containing serum as well as the four main components of JZN and Atorvastatin.
The mRNA expression of LDL receptor (LDL-R), 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoAR), cytochrome P450 7A1 (CYP7A1), and acetyl-Coenzyme A acetyltransferase 2 (ACAT2) was measured by real-time PCR.
LDL-R surface expression and LDL-binding and internalization were examined by flow cytometry.
The results showed that JZN-containing serum significantly increased the mRNA expression of LDL-R, HMG-CoAR, and CYP7A1 in Bel-7402 cells.
All the four components significantly increased the mRNA and protein expression of LDL-R and HMG-CoAR and decreased the mRNA and protein expression of ACAT2 in Bel-7402 cells.
Hyperinand chrysophanol also markedly increased the mRNA expression of CYP7A1.
Stimulation with stilbene glycosidesignificantly increased the surface expression of LDL-R and the binding and internalization of LDL.
In conclusion, JZN and its four components have close relationship with the process of cholesterol metabolism, emphasizing their promising application as new drug candidates in the treatment of hyperlipidemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Jianxin& Zhao, Huihui& Ma, Xueling& Han, Xiao& Luo, Liangtao& Wang, Luya…[et al.]. 2012. The Effects of Jiang-Zhi-Ning and Its Main Components on Cholesterol Metabolism. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028624
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Jianxin…[et al.]. The Effects of Jiang-Zhi-Ning and Its Main Components on Cholesterol Metabolism. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028624
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Jianxin& Zhao, Huihui& Ma, Xueling& Han, Xiao& Luo, Liangtao& Wang, Luya…[et al.]. The Effects of Jiang-Zhi-Ning and Its Main Components on Cholesterol Metabolism. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028624
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028624
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر