Effects of a Chinese Herbal Medicine, Guan-Jen-Huang (Aeginetia indica Linn.), on Renal Cancer Cell Growth and Metastasis
المؤلفون المشاركون
Liu, Yu-Huei
Lin, Jung-Yaw
Li, Meng-Luen
Hsu, Meng-Yu
Pang, Ya-Yueh
Chen, I-Ling
Chen, Ching-Kuei
Tang, Sai-Wen
Lin, Hsuan-Yuan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aeginetia indica Linn.
(Guan-Jen-Huang, GJH), a traditional Chinese herb, has the potential to be an immunomodulatory agent.
The purpose of this study was to explore the effect of GJH in the treatment of renal cancer.
Concentration-effect curves for the influence of GJH on cellular proliferation showed a biphasic shape.
Besides, GJH had a synergistic effect on cytotoxicity when combined with 5-fluorouracil (5-FU)which may be due to the alternation of the chemotherapeutic agent resistance-related genes and due to the synergistic effects on apoptosis.
In addition, treatment with GJH extract markedly reduced 786-O cell adherence to human umbilical vein endothelial cells (HUVECs) and decreased 786-O cell migration and invasion.
In a xenograft animal model, GJH extract had an inhibitory effect on tumor cell-induced metastasis.
Moreover, western blot analysis showed that the expression of intercellular adhesion molecule-1 (ICAM-1) in 786-O cells was significantly decreased by treatment with GJH extract through inactivation of nuclear factor-κB (NF–κB).
These results suggest that GJH extract has a synergistic effect on apoptosis induced by chemotherapeutic agents and an inhibitory effect on cell adhesion, migration, and invasion, providing evidence for the use of water-based extracts of GJH as novel alternative therapeutic agents in the treatment of human renal cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Yu-Huei& Li, Meng-Luen& Hsu, Meng-Yu& Pang, Ya-Yueh& Chen, I-Ling& Chen, Ching-Kuei…[et al.]. 2011. Effects of a Chinese Herbal Medicine, Guan-Jen-Huang (Aeginetia indica Linn.), on Renal Cancer Cell Growth and Metastasis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028634
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Yu-Huei…[et al.]. Effects of a Chinese Herbal Medicine, Guan-Jen-Huang (Aeginetia indica Linn.), on Renal Cancer Cell Growth and Metastasis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028634
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Yu-Huei& Li, Meng-Luen& Hsu, Meng-Yu& Pang, Ya-Yueh& Chen, I-Ling& Chen, Ching-Kuei…[et al.]. Effects of a Chinese Herbal Medicine, Guan-Jen-Huang (Aeginetia indica Linn.), on Renal Cancer Cell Growth and Metastasis. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028634
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028634
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر