Antiplatelet, Antithrombotic, and Fibrinolytic Activities of Campomanesia xanthocarpa
المؤلفون المشاركون
Schetinger, Maria Rosa Chitolina
Leal, Cláudio Alberto Martins
Klafke, Jonatas Zeni
Arnoldi da Silva, Mariane
Fortes Rossato, Mateus
Trevisan, Gabriela
Banderó Walker, Cristiani Isabel
Olschowsky Borges, Diego
Noal Moresco, Rafael
Soares dos Santos, Adair Roberto
Nazário Viecili, Paulo Ricardo
Ferreira, Juliano
Medeiros Frescura Duarte, Marta Maria
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-09-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
In a previous work based on popular belief, Campomanesia xanthocarpa Berg., popularly known as “guavirova”, showed to have a potential effect in the control of a number of conditions associated with cardiovascular diseases.
The aim of the present work was to investigate the effects of C.
xanthocarpa extract (CXE) on antiplatelet, antithrombotic and fibrinolytic activities in mice and in human blood.
Mice were treated orally for 5 days with CXE or acetylsalicylic acid and at the end of the treatment period animals were challenged for bleeding, acute thromboembolism and ulcerogenic activity.
In addition, we have assessed the prothrombin time and activated partial thromboplastin time (aPTT) after oral administration.
In in vitro assays, antiplatelet effects of CXE was evaluated on platelet aggregation, and fibrinolytic activity of the extract was observed by mice or human artificial blood clot degradation.
Platelet citotoxicity of the extract was also determined by the LDH assay.
Results demonstrated that CXE has a significant protective effect on thrombosis.
It also inhibits platelet aggregation without demonstrating cytotoxicity on platelets.
CXE slightly prolonged aPTT and showed no ulcerogenic activity after oral administration.
In addition, CXE showed a fibrinolytic activity.
Thus, C.
xanthocarpa showed antiplatelet, antithrombotic and fibrinolytic activities in mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Klafke, Jonatas Zeni& Arnoldi da Silva, Mariane& Fortes Rossato, Mateus& Trevisan, Gabriela& Banderó Walker, Cristiani Isabel& Leal, Cláudio Alberto Martins…[et al.]. 2011. Antiplatelet, Antithrombotic, and Fibrinolytic Activities of Campomanesia xanthocarpa. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028648
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Klafke, Jonatas Zeni…[et al.]. Antiplatelet, Antithrombotic, and Fibrinolytic Activities of Campomanesia xanthocarpa. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028648
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Klafke, Jonatas Zeni& Arnoldi da Silva, Mariane& Fortes Rossato, Mateus& Trevisan, Gabriela& Banderó Walker, Cristiani Isabel& Leal, Cláudio Alberto Martins…[et al.]. Antiplatelet, Antithrombotic, and Fibrinolytic Activities of Campomanesia xanthocarpa. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028648
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028648
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر