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Korean Red Ginseng Suppresses Metastasis of Human Hepatoma SK-Hep1 Cells by Inhibiting Matrix Metalloproteinase-2-9 and Urokinase Plasminogen Activator
المؤلفون المشاركون
Chang, Yuan-Shiun
Ho, Yu-Ling
Li, Kun-Cheng
Chao, Wei
Huang, Guan-Jhong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Korean red ginseng and ginsenosides have been claimed to possess wide spectrum of medicinal effects, of which anticancer effect is one.
The present study was undertaken to investigate the antimetastatic effect of Korean red ginseng on human hepatoma as well as possible mechanisms.
The inhibitory effect of the water extract of Korean red ginseng (WKRG) on the invasion and motility of SK-Hep1 cells was evaluated by the Boyden chamber assay in vitro.
Without causing cytotoxicity, WKRG exerted a dose-dependent inhibitory effect on the invasion and motility, but not adhesion, of highly metastatic SK-Hep1 cells.
Zymography analyses revealed significant downregulating effects on MMP-2, MMP-9, and uPA activities in SK-Hep1 cells.
Western blot analyses also showed that WKRG treatment caused dose-dependent decreases in MMP-2 and MMP-9 protein expressions.
Moreover, WKRG increased the levels of TIMP-1, TIMP-2, and PAI-1.
The present study not only demonstrated that invasion and motility of cancer cells were inhibited by WKRG, but also indicated that such effects were likely associated with the decrease in MMP-2/-9 and uPA expressions of SK-Hep1 cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ho, Yu-Ling& Li, Kun-Cheng& Chao, Wei& Chang, Yuan-Shiun& Huang, Guan-Jhong. 2012. Korean Red Ginseng Suppresses Metastasis of Human Hepatoma SK-Hep1 Cells by Inhibiting Matrix Metalloproteinase-2-9 and Urokinase Plasminogen Activator. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028654
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ho, Yu-Ling…[et al.]. Korean Red Ginseng Suppresses Metastasis of Human Hepatoma SK-Hep1 Cells by Inhibiting Matrix Metalloproteinase-2-9 and Urokinase Plasminogen Activator. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028654
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ho, Yu-Ling& Li, Kun-Cheng& Chao, Wei& Chang, Yuan-Shiun& Huang, Guan-Jhong. Korean Red Ginseng Suppresses Metastasis of Human Hepatoma SK-Hep1 Cells by Inhibiting Matrix Metalloproteinase-2-9 and Urokinase Plasminogen Activator. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028654
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028654
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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