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Protective Effect of the Fruit Hull of Gleditsia sinensis on LPS-Induced Acute Lung Injury Is Associated with Nrf2 Activation
المؤلفون المشاركون
Sadikot, Ruxana
Joo, Myungsoo
Christman, John W.
Lee, Beom-Joon
Choi, Jun-Yong
Kim, Kyun Ha
Kwun, Min Jung
Lyu, Ji Hyo
Han, Chang Woo
Jeong, Han-Sol
Ha, Ki-Tae
Jung, Hee-Jae
Jung, Sung-ki
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-01-29
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The fruit hull of Gleditsia sinensis (FGS) has been prescribed as a traditional eastern Asian medicinal remedy for the treatment of various respiratory diseases, but the efficacy and underlying mechanisms remain poorly characterized.
Here, we explored a potential usage of FGS for the treatment of acute lung injury (ALI), a highly fatal inflammatory lung disease that urgently needs effective therapeutics, and investigated a mechanism for the anti-inflammatory activity of FGS.
Pretreatment of C57BL/6 mice with FGS significantly attenuated LPS-induced neutrophilic lung inflammation compared to sham-treated, inflamed mice.
Reporter assays, semiquantitative RT-PCR, and Western blot analyses show that while not affecting NF-κB, FGS activated Nrf2 and expressed Nrf2-regulated genes including GCLC, NQO-1, and HO-1 in RAW 264.7 cells.
Furthermore, pretreatment of mice with FGS enhanced the expression of GCLC and HO-1 but suppressed that of proinflammatory cytokines in including TNF-α and IL-1β in the inflamed lungs.
These results suggest that FGS effectively suppresses neutrophilic lung inflammation, which can be associated with, at least in part, FGS-activating anti-inflammatory factor Nrf2.
Our results suggest that FGS can be developed as a therapeutic option for the treatment of ALI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Choi, Jun-Yong& Kwun, Min Jung& Kim, Kyun Ha& Lyu, Ji Hyo& Han, Chang Woo& Jeong, Han-Sol…[et al.]. 2012. Protective Effect of the Fruit Hull of Gleditsia sinensis on LPS-Induced Acute Lung Injury Is Associated with Nrf2 Activation. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028662
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Choi, Jun-Yong…[et al.]. Protective Effect of the Fruit Hull of Gleditsia sinensis on LPS-Induced Acute Lung Injury Is Associated with Nrf2 Activation. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028662
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Choi, Jun-Yong& Kwun, Min Jung& Kim, Kyun Ha& Lyu, Ji Hyo& Han, Chang Woo& Jeong, Han-Sol…[et al.]. Protective Effect of the Fruit Hull of Gleditsia sinensis on LPS-Induced Acute Lung Injury Is Associated with Nrf2 Activation. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028662
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028662
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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