Decreased Skin-Mediated Detoxification Contributes to Oxidative Stress and Insulin Resistance
المؤلفون المشاركون
Li, Chun-Yan
Zhou, Shi-Sheng
Cao, Yu
Liu, Xing-Xing
Guo, Ming
Tian, Yan-Jie
Li, Da
Sun, Chang-Bin
Yang, Ting-Tong
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The skin, the body's largest organ, plays an important role in the biotransformation/detoxification and elimination of xenobiotics and endogenous toxic substances, but its role in oxidative stress and insulin resistance is unclear.
We investigated the relationship between skin detoxification and oxidative stress/insulin resistance by examining burn-induced changes in nicotinamide degradation.
Rats were divided into four groups: sham-operated, sham-nicotinamide, burn, and burn-nicotinamide.
Rats received an intraperitoneal glucose injection (2 g/kg) with (sham-nicotinamide and burn-nicotinamide groups) or without (sham-operated and burn groups) coadministration of nicotinamide (100 mg/kg).
The results showed that the mRNA of all detoxification-related enzymes tested was detected in sham-operated skin but not in burned skin.
The clearance of nicotinamide and N1-methylnicotinamide in burned rats was significantly decreased compared with that in sham-operated rats.
After glucose loading, burn group showed significantly higher plasma insulin levels with a lower muscle glycogen level than that of sham-operated and sham-nicotinamide groups, although there were no significant differences in blood glucose levels over time between groups.
More profound changes in plasma H2O2 and insulin levels were observed in burn-nicotinamide group.
It may be concluded that decreased skin detoxification may increase the risk for oxidative stress and insulin resistance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Xing-Xing& Sun, Chang-Bin& Yang, Ting-Tong& Li, Da& Li, Chun-Yan& Tian, Yan-Jie…[et al.]. 2012. Decreased Skin-Mediated Detoxification Contributes to Oxidative Stress and Insulin Resistance. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029071
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Xing-Xing…[et al.]. Decreased Skin-Mediated Detoxification Contributes to Oxidative Stress and Insulin Resistance. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-1029071
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Xing-Xing& Sun, Chang-Bin& Yang, Ting-Tong& Li, Da& Li, Chun-Yan& Tian, Yan-Jie…[et al.]. Decreased Skin-Mediated Detoxification Contributes to Oxidative Stress and Insulin Resistance. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029071
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1029071
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر