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Telomere Length Attrition, a Marker of Biological Senescence, Is Inversely Correlated with Triglycerides and Cholesterol in South Asian Males with Type 2 Diabetes Mellitus
المؤلفون المشاركون
al-Daghri, Nasser M.
Miller, Michelle A.
Kelly, Ann
McTernan, Philip G.
Bellary, Srikanth
Alokail, Majed
da Silva, Nancy F.
Cappuccio, Francesco P.
Harte, Alison L.
al-Attas, Omar
Kumar, Sudhesh
Barnett, Anthony H.
Tripathi, Gyanendra
Sabico, Shaun
O’Hare, Joseph P.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
South Asians have a higher risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) than white Caucasians, for a given BMI.
Premature biological ageing, assessed by reduction in telomere length (TL), may be mediated by factors resulting from altered metabolic profiles associated with obesity.
We hypothesise that ethnicity and metabolic status represent detrimental factors contributing to premature biological ageing.
Therefore we assessed TL in two South Asian, age and BMI-matched cohorts [T2DM (n=142) versus non-T2DM (n=76)] to determine the effects of BMI, gender, lipid and CVD profile on biological ageing.
Genomic DNA was obtained from the UKADS cohort; biochemical and anthropometric data was collected and TL was measured by quantitative real-time PCR.
Our findings indicated a gender-specific effect with reduced TL in T2DM men compared with non-T2DM men (P=0.006).
Additionally, in T2DM men, TL was inversely correlated with triglycerides and total cholesterol (r=−0.419, P<0.01; r=−0.443, P<0.01).
In summary, TL was reduced amongst South Asian T2DM men and correlated with triglycerides and total cholesterol.
This study highlights enhanced biological ageing among South Asian, T2DM men, which appears to be tracked by changes in lipids and BMI, suggesting that raised lipids and BMI may directly contribute to premature ageing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Harte, Alison L.& da Silva, Nancy F.& Miller, Michelle A.& Cappuccio, Francesco P.& Kelly, Ann& O’Hare, Joseph P.…[et al.]. 2012. Telomere Length Attrition, a Marker of Biological Senescence, Is Inversely Correlated with Triglycerides and Cholesterol in South Asian Males with Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029091
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Harte, Alison L.…[et al.]. Telomere Length Attrition, a Marker of Biological Senescence, Is Inversely Correlated with Triglycerides and Cholesterol in South Asian Males with Type 2 Diabetes Mellitus. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-1029091
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Harte, Alison L.& da Silva, Nancy F.& Miller, Michelle A.& Cappuccio, Francesco P.& Kelly, Ann& O’Hare, Joseph P.…[et al.]. Telomere Length Attrition, a Marker of Biological Senescence, Is Inversely Correlated with Triglycerides and Cholesterol in South Asian Males with Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029091
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1029091
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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