Effect of Molecular Weight and Molar Ratio of Dextran on Self-Assembly of Dextran Stearate Polymeric Micelles as Nanocarriers for Etoposide
المؤلفون المشاركون
Varshosaz, Jaleh
Mirian, Mina
Firozian, Farzin
Hassanzadeh, Farshid
Sadeghi-Aliabadi, Hojjat
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Amphiphilic polymer surfactants are composed of hydrophilic and hydrophobic polymers and are widely used in targeted drug delivery.
The purpose of this study was the evaluation of the effect of molecular weight and molar ratio of dextran on physicochemical properties of dextran stearate polymeric micelles.
Dextran stearate was synthesized by acylation of dextran with stearoyl chloride.
Etoposide loaded polymeric micelles were prepared by dialysis method.
The resulting micelles were evaluated for particle size, zeta potential, critical micelle concentration (CMC), drug loading capacity, and release efficiency.
Cytotoxicity and cellular uptake of micelles were studied in CT-26 colorectal carcinoma cell line.
Molecular weight and molar ratio of dextran-stearate were impressive on zeta potential, CMC, drug loading capacity, and release efficiency.
Unlike polymer molecular weight, molar ratio of stearate had a significant effect on cytotoxicity and particle size of etoposide loaded micelles.
Although molecular weight of dextran had no significant effect on cytotoxicity of micelles on CT-26 cells, it had drastic attributes for stability of polymeric micelles.
Consequently, both variables of molecular weight of dextran and molar ratio of stearate should be taken into account to have a stable and effective micelle of dextran-stearate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Varshosaz, Jaleh& Hassanzadeh, Farshid& Sadeghi-Aliabadi, Hojjat& Firozian, Farzin& Mirian, Mina. 2012. Effect of Molecular Weight and Molar Ratio of Dextran on Self-Assembly of Dextran Stearate Polymeric Micelles as Nanocarriers for Etoposide. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029173
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Varshosaz, Jaleh…[et al.]. Effect of Molecular Weight and Molar Ratio of Dextran on Self-Assembly of Dextran Stearate Polymeric Micelles as Nanocarriers for Etoposide. Journal of Nanomaterials No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1029173
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Varshosaz, Jaleh& Hassanzadeh, Farshid& Sadeghi-Aliabadi, Hojjat& Firozian, Farzin& Mirian, Mina. Effect of Molecular Weight and Molar Ratio of Dextran on Self-Assembly of Dextran Stearate Polymeric Micelles as Nanocarriers for Etoposide. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029173
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1029173
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر