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Atherosclerosis and Rheumatoid Arthritis: More Than a Simple Association
المؤلفون المشاركون
Caporali, Roberto
Boffini, Nicola
Cagnotto, Giovanni
Inverardi, Flora
Grosso, Vittorio
Cavagna, Lorenzo
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
In the last decades a large amount of evidence linked rheumatoid arthritis (RA) to atherosclerosis.
In fact, RA patients have an increased risk of cardiovascular events that is not fully explained by other classic cardiovascular risk factors.
RA and atherosclerosis may share several common pathomechanisms and inflammation undoubtedly plays a primary role.
The proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-6, involved in the pathogenesis of RA, are also independently predictive of subsequent cardiovascular disease (CVD).
In RA, inflammation alters HDL constituents and the concentration of LDL and HDL, thus facilitating atherosclerosis and CVD events.
On the other hand, also the increase of oxidative processes, frequently observed in RA, induces atherosclerosis.
Interestingly, some genetic polymorphisms associated with RA occurrence enhance atherosclerosis, however, other polymorphisms associated with RA susceptibility do not increase CVD risk.
Several other mechanisms may influence atherosclerotic processes in RA.
Moreover, atherosclerosis may be directly mediated also by underlying autoimmune processes, and indirectly by the occurrence of metabolic syndrome and impaired physical activity.
Finally, the effects of RA therapies on cardiovascular system in general and on atherosclerosis in particular are really wide and different.
However, the starting point of every RA treatment is that disease control, or better remission, is the best way we have for the reduction of CVD occurrence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cavagna, Lorenzo& Boffini, Nicola& Cagnotto, Giovanni& Inverardi, Flora& Grosso, Vittorio& Caporali, Roberto. 2012. Atherosclerosis and Rheumatoid Arthritis: More Than a Simple Association. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029369
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cavagna, Lorenzo…[et al.]. Atherosclerosis and Rheumatoid Arthritis: More Than a Simple Association. Mediators of Inflammation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1029369
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cavagna, Lorenzo& Boffini, Nicola& Cagnotto, Giovanni& Inverardi, Flora& Grosso, Vittorio& Caporali, Roberto. Atherosclerosis and Rheumatoid Arthritis: More Than a Simple Association. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029369
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1029369
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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