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Mast Cells and Histamine: Do They Influence Placental Vascular Network and Development in Preeclampsia?
المؤلفون المشاركون
Szewczyk, Grzegorz
Szukiewicz, Dariusz
Pyzlak, Michał
Klimkiewicz, Jakub
Śmiertka, Wacław
Miedzińska-Maciejewska, Magdalena
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-19
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The physiological course of pregnancy is closely related to adequate development of the placenta.
Shallow invasion of trophoblast as well as decreased development of the placental vascular network are both common features of preeclampsia.
To better understand the proangiogenic features of mast cells, in this study we aim to identify the potential relationship between the distribution of mast cells within the placenta and vascular network development.
Material and Methods.
Placentas from preeclampsia-complicated pregnancies (n=11) and from physiological pregnancies (n=11) were acquired after cesarean section.
The concentration of histamine was measured, and immunohistochemical staining for mast cell tryptase was performed.
Morphometric analysis was then performed.
Results.
We noticed significant differences between the examined groups.
Notably, in the preeclampsia group compared to the control group, we observed a higher mean histamine concentration, higher mast cell density (MCD), lower mean mast cell (MMCA) and lower vascular/extravascular (V/EVT) index.
In physiological pregnancies, a positive correlation was observed between the histamine concentration and V/VEVT index as well as MCD and the V/VEVT index.
In contrast, a negative correlation was observed between MMCA and the V/EVT index in physiological pregnancies.
Conclusions.
Based on the data from our study, we suggest that a differential distribution of mast cells and corresponding changes in the concentration of histamine are involved in the defective placental vascularization seen in preeclamptic placentas.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Szewczyk, Grzegorz& Pyzlak, Michał& Klimkiewicz, Jakub& Śmiertka, Wacław& Miedzińska-Maciejewska, Magdalena& Szukiewicz, Dariusz. 2012. Mast Cells and Histamine: Do They Influence Placental Vascular Network and Development in Preeclampsia?. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1029387
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Szewczyk, Grzegorz…[et al.]. Mast Cells and Histamine: Do They Influence Placental Vascular Network and Development in Preeclampsia?. Mediators of Inflammation No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-1029387
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Szewczyk, Grzegorz& Pyzlak, Michał& Klimkiewicz, Jakub& Śmiertka, Wacław& Miedzińska-Maciejewska, Magdalena& Szukiewicz, Dariusz. Mast Cells and Histamine: Do They Influence Placental Vascular Network and Development in Preeclampsia?. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1029387
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1029387
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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