Psychological Stress Delays Periodontitis Healing in Rats: The Involvement of Basic Fibroblast Growth Factor
المؤلفون المشاركون
Zhao, Ya-Juan
Cheng, Bai-Xiang
Chen, Yong-Jin
Li, Qiang
Zhang, Min
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-30
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Objective.
To evaluate the effects of psychological stress on periodontitis healing in rats and the contribution of basic fibroblast growth factor (bFGF) expression to the healing process.
Methods.
Ninety-six rats were randomly distributed into control group, periodontitis group, and periodontitis plus stress group.
Then, the rats were sacrificed at baseline and week(s) 1, 2, and 4.
The periodontitis healing condition was assessed, and the expression of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and bFGF were tested by immunohistochemistry.
Results.
The stressed rats showed reduced body weight gain, behavioral changes, and increased serum corticosterone and ACTH levels (P<0.05).
The surface of inflammatory infiltrate, alveolar bone loss, attachment loss, and expression of IL-1β and TNF-α in the stress group were higher than those in the periodontitis group at weeks 2 and 4 (P<0.05).
Rats with experimental periodontitis showed decreased bFGF expression (P<0.05), and the recovery of bFGF expression in the stress group was slower than that in the periodontitis group (P<0.05).
Negative correlations between inflammatory cytokines and bFGF were detected.
Conclusion.
Psychological stress could delay periodontitis healing in rats, which may be partly mediated by downregulation of the expression of bFGF in the periodontal ligament.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Ya-Juan& Li, Qiang& Cheng, Bai-Xiang& Zhang, Min& Chen, Yong-Jin. 2012. Psychological Stress Delays Periodontitis Healing in Rats: The Involvement of Basic Fibroblast Growth Factor. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1029436
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Ya-Juan…[et al.]. Psychological Stress Delays Periodontitis Healing in Rats: The Involvement of Basic Fibroblast Growth Factor. Mediators of Inflammation No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-1029436
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Ya-Juan& Li, Qiang& Cheng, Bai-Xiang& Zhang, Min& Chen, Yong-Jin. Psychological Stress Delays Periodontitis Healing in Rats: The Involvement of Basic Fibroblast Growth Factor. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1029436
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1029436
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر